Palliative Thoracic Radiotherapy for Non-small Cell Lung Cancer: Is There any Impact of Target Volume Size on Survival?
| Autor: | Carsten Nieder, Bård Mannsåker, Rosalba Yobuta, Kristian S. Imingen |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Oncology
Male Cancer Research medicine.medical_specialty Multivariate analysis Lung Neoplasms medicine.medical_treatment Planning target volume Internal medicine Carcinoma Non-Small-Cell Lung medicine Humans Stage (cooking) Lung cancer Aged Neoplasm Staging Retrospective Studies Aged 80 and over business.industry Radiotherapy Planning Computer-Assisted Palliative Care Retrospective cohort study Radiotherapy Dosage General Medicine Middle Aged medicine.disease Prognosis Tumor Burden Radiation therapy Treatment Outcome Female Radiotherapy Adjuvant Non small cell business Chemoradiotherapy |
| Zdroj: | Anticancer research. 41(1) |
| ISSN: | 1791-7530 |
| Popis: | Background/aim Recent studies suggested that target volume size impacts survival in patients with non-small cell lung cancer (NSCLC) receiving radical radiotherapy. Little is known about the impact of target volume size in palliative radiotherapy or chemoradiotherapy. Therefore, we analyzed the overall survival stratified for clinical and planning target volume (CTV and PTV) size. Patients and methods A retrospective study of 77 patients who received palliative (chemo)radiotherapy (at least 30 Gy) for non-metastatic NSCLC, largely stage III was performed. Typical radiation doses were 10-13 fractions of 3 Gy and 15 fractions of 2.8 Gy. Results Median survival was 12 months (2-year rate 18%). Three prognostic factors emerged in the multivariate analysis. Hospitalization in the last 4 weeks before radiotherapy increased the hazard of death by a factor of 2.8 (p=0.002). Presence of a T1 or 2 tumor decreased the hazard of death by a factor of 0.5 (p=0.03). Concomitant chemoradiotherapy decreased the hazard of death by a factor of 0.4 (p=0.003). Conclusion Target volume size was not significantly associated with survival, suggesting that large size should not preclude palliative (chemo)radiotherapy as long as normal tissue dose constraints can be met. |
| Databáze: | OpenAIRE |
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