Repositioning TH cell polarization from single cytokines to complex help

Autor: Thomas Korn, Francisco J. Quintana, Matteo Iannacone, Florent Ginhoux, Anne Dejean, Burkhard Becher, Selma Tuzlak, Ari Waisman
Přispěvatelé: Universität Zürich [Zürich] = University of Zurich (UZH), Institut Toulousain des Maladies Infectieuses et Inflammatoires (Infinity), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), IRCCS San Raffaele Scientific Institute [Milan, Italie], Universita Vita Salute San Raffaele = Vita-Salute San Raffaele University [Milan, Italie] (UniSR), Brigham & Women’s Hospital [Boston] (BWH), Harvard Medical School [Boston] (HMS), University Medical Center of the Johannes Gutenberg-University Mainz, Singapore Immunology Network (SIgN), Biomedical Sciences Institute (BMSI), Duke-NUS Medical School [Singapore], Shangaï Jiao Tong University [Shangaï], Technische Universität München = Technical University of Munich (TUM), Munich Cluster for systems neurology [Munich] (SyNergy), Technische Universität Munchen - Université Technique de Munich [Munich, Allemagne] (TUM)-Ludwig-Maximilians-Universität München (LMU), ARSEP foundation (ARSEP R19191BB, FRM (R20097BB), Italian Ministry of Health grants RF-2018-12365801 and COVID-2020-12371617, Lombardy Foundation for Biomedical Research grant 2015-0010, ANR-16-CE15-0007,FOxOTiC,Rôle du facteur de transcription Foxo3 dans les lymphocytes T CD4(2016), European Project: 957502,ERC, Tuzlak, S., Dejean, A. S., Iannacone, M., Quintana, F. J., Waisman, A., Ginhoux, F., Korn, T., Becher, B., Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Pistre, Karine, Rôle du facteur de transcription Foxo3 dans les lymphocytes T CD4 - - FOxOTiC2016 - ANR-16-CE15-0007 - AAPG2016 - VALID, Proof of Concept grant - ERC - 957502 - INCOMING
Jazyk: angličtina
Rok vydání: 2021
Předmět:
[SDV.IMM] Life Sciences [q-bio]/Immunology
[SDV]Life Sciences [q-bio]
Immunology
Cell
Cell Plasticity
MESH: Cell Plasticity / immunology
[SDV.BC]Life Sciences [q-bio]/Cellular Biology
Biology
Epithelium
03 medical and health sciences
0302 clinical medicine
Immune system
MESH: Eosinophils / immunology
MESH: Phagocytes / immunology
Cell polarity
medicine
Immunology and Allergy
Animals
Humans
MESH: Animals
MESH: Cytokines / immunology
Lymphocytes
Transcription factor
[SDV.BC] Life Sciences [q-bio]/Cellular Biology
MESH: Immunity
Innate / immunology
030304 developmental biology
0303 health sciences
B-Lymphocytes
Phagocytes
MESH: Epithelium / immunology
MESH: Humans
Innate lymphoid cell
T-Lymphocytes
Helper-Inducer
Phenotype
Immunity
Innate
Cell biology
MESH: B-Lymphocytes / immunology
[SDV] Life Sciences [q-bio]
Eosinophils
MESH: Lymphocytes / immunology
medicine.anatomical_structure
Cytokines
[SDV.IMM]Life Sciences [q-bio]/Immunology
MESH: T-Lymphocytes
Helper-Inducer / immunology
030215 immunology
Zdroj: Nature Immunology
Nature Immunology, 2021, 22 (10), pp.1210-1217. ⟨10.1038/s41590-021-01009-w⟩
ISSN: 1529-2908
1529-2916
DOI: 10.1038/s41590-021-01009-w⟩
Popis: International audience; When helper T (TH) cell polarization was initially described three decades ago, the TH cell universe grew dramatically. New subsets were described based on their expression of few specific cytokines. Beyond TH1 and TH2 cells, this led to the coining of various TH17 and regulatory (Treg) cell subsets as well as TH22, TH25, follicular helper (TFH), TH3, TH5 and TH9 cells. High-dimensional single-cell analysis revealed that a categorization of TH cells into a single-cytokine-based nomenclature fails to capture the complexity and diversity of TH cells. Similar to the simple nomenclature used to describe innate lymphoid cells (ILCs), we propose that TH cell polarization should be categorized in terms of the help they provide to phagocytes (type 1), to B cells, eosinophils and mast cells (type 2) and to non-immune tissue cells, including the stroma and epithelium (type 3). Studying TH cells based on their helper function and the cells they help, rather than phenotypic features such as individual analyzed cytokines or transcription factors, better captures TH cell plasticity and conversion as well as the breadth of immune responses in vivo.
Databáze: OpenAIRE
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