Clinical significance of apoptotic index in non-small cell lung cancer: correlation with p53, mdm2, pRb and p21WAF1/CIP1 protein expression
| Autor: | Marcin Gruchała, T. Wirth, Andrzej Rynkiewicz, Kazimierz Jaśkiewicz, Dorota Dworakowska, Andrzej Karmolinski, Ewa Jassem, Seppo Ylä-Herttuala, Rafal Dworakowski, Jan Skokowski, Jacek Jassem, Eugenia Czestochowska |
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| Rok vydání: | 2005 |
| Předmět: |
Oncology
Cyclin-Dependent Kinase Inhibitor p21 Male Cancer Research medicine.medical_specialty Lung Neoplasms Tumor suppressor gene Apoptosis Retinoblastoma Protein Internal medicine Carcinoma Non-Small-Cell Lung Gene expression medicine Biomarkers Tumor In Situ Nick-End Labeling Humans Clinical significance Lung cancer neoplasms Aged Hematology biology Respiratory disease Proto-Oncogene Proteins c-mdm2 General Medicine Middle Aged medicine.disease Prognosis Immunohistochemistry Survival Analysis Survival Rate biology.protein Cancer research Mdm2 Female Tumor Suppressor Protein p53 |
| Zdroj: | Journal of cancer research and clinical oncology. 131(9) |
| ISSN: | 0171-5216 |
| Popis: | Purpose: The aim of this study was to assess the prognostic relevance of apoptotic index (AI), considered alone or together with expression of several proteins controlling G1 check point (p53, mdm2, pRb and p21WAF1/CIP1) in non-small cell lung cancer (NSCLC) patients. Methods: Study group included 50 NSCLC patients who underwent curative pulmonary resection. Apoptosis was detected with the use of TUNEL technique and AI was defined as the number of apoptotic cells per 1,000 tumor cells. The expression of p53, mdm2, pRb and p21WAF1/CIP1 was assessed immunohistochemically. Results: The mean and median AI calculated for all 50 patients was 14 and 9, respectively. Patients with lower ( |
| Databáze: | OpenAIRE |
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