Therapy potential for the correction of cardiovascular disturbances in diabetes mellitus
| Autor: | A. G. Mordovina, O I Morozova, E. V. Rubleva, N. V. Pozdnyakova, I. P. Tatarchenko |
|---|---|
| Jazyk: | ruština |
| Rok vydání: | 2012 |
| Předmět: |
medicine.medical_specialty
business.industry cardiac remodelling medicine.disease endothelial dysfunction Internal medicine Diabetes mellitus RC666-701 diabetes mellitus medicine angiotensin receptor antagonists Diseases of the circulatory (Cardiovascular) system Cardiology and Cardiovascular Medicine business |
| Zdroj: | Кардиоваскулярная терапия и профилактика, Vol 11, Iss 4, Pp 59-64 (2012) |
| ISSN: | 2619-0125 1728-8800 |
| Popis: | Aim. To study the dynamics of left ventricular (LV) structure and function, as well as vasomotor activity of arterial endothelium, in patients with Type 2 diabetes mellitus (DM-2) and diastolic heart failure (DHF) who are treated with an angiotensin II receptor antagonist olmesartan. Material and methods. The study included 56 patients (26 men and 30 women; mean age 58,2±5,3 years) with NYHA Functional Class I-II chronic heart failure (CHF), diastolic LV dysfunction (abnormal relaxation), and LV ejection fraction (EF) >50%. Other inclusion criteria were DM-2 duration Results. The major pathogenetic mechanisms of LV diastolic dysfunction and endothelial dysfunction in DM-2 are linked to the development of central sympathetic hyperactivation and activation of the tissue reninangiotensin system. Conclusion. After 30 weeks of olmesartan therapy, LV structure and geometry, LV diastolic function, and vasomotor activity of arterial endothelium had improved, which was expected to reduce the risk of myocardial ischemia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|