T1-weighted dynamic contrast-enhanced brain magnetic resonance imaging: A preliminary study with low infusion rate in pediatric patients
| Autor: | Dominique Sirinelli, Catherine Sembely-Taveau, Baptiste Morel, Bénédicte Maréchal, Kathleen Gaillot, Jean-Philippe Cottier, Bruno-Bernard Rochetams |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
Intracranial Arteriovenous Malformations
Male Contrast Media Neuroimaging 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Imaging Three-Dimensional Meglumine Image Interpretation Computer-Assisted medicine T1 weighted Organometallic Compounds Humans Radiology Nuclear Medicine and imaging Brain magnetic resonance imaging Neuroimaging in Pediatrics Prospective Studies Child medicine.diagnostic_test business.industry Brain Neoplasms Magnetic resonance imaging General Medicine Magnetic Resonance Imaging Stroke Pediatric Radiology Dynamic contrast Dynamic contrast-enhanced MRI Female Neurology (clinical) Neoplasm Grading business Nuclear medicine 030217 neurology & neurosurgery |
| Popis: | Background The aim of this preliminary study is to evaluate the results of T1-weighted dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) in pediatric patients at 1.5T, with a low peripheral intravenous gadoteric acid injection rate of 1 ml/s. Materials and methods Children with neurological symptoms were examined prospectively with conventional MRI and T1-weighted DCE MRI. An magnetic resonance perfusion analysis method was used to obtain time–concentration curves (persistent pattern, type-I; plateau pattern, type-II; washout pattern, type-III) and to calculate pharmacokinetic parameters. A total of two radiologists manually defined regions of interest (ROIs) in the part of the lesion exhibiting the greatest contrast enhancement and in the surrounding normal or contralateral tissue. Lesion/surrounding tissue or contralateral tissue pharmacokinetic parameter ratios were calculated. Tumors were categorized by grade (I–IV) using the World Health Organization (WHO) Grade. Mann–Whitney testing and receiver-operating characteristic (ROC) curves were performed. Results A total of nine boys and nine girls (mean age 10.5 years) were included. Lesions consisted of 10 brain tumors, 3 inflammatory lesions, 3 arteriovenous malformations and 2 strokes. We obtained analyzable concentration–time curves for all patients (6 type-I, 9 type-II, 3 type-III). Ktrans between tumor tissue and surrounding or contralateral tissue was significantly different ( p = 0.034). Ktrans ratios were significantly different between grade I tumors and grade IV tumors ( p = 0.027) and a Ktrans ratio value superior to 0.63 appeared to be discriminant to determine a grade IV of malignancy. Conclusions Our results confirm the feasibility of pediatric T1-weighted DCE MRI at 1.5T with a low injection rate, which could be of great value in differentiating brain tumor grades. |
| Databáze: | OpenAIRE |
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