Ergosterol biosynthesis and its inhibition by fenpropimorph in Fusarium species

Autor: Danièle Debieu, Jocelyne Bach, Pierre Leroux, Michel Gredt, Claude Gall, Christian Malosse
Přispěvatelé: Unité de phytopharmacie et médiateurs chimiques, Institut National de la Recherche Agronomique (INRA), ProdInra, Migration
Rok vydání: 1992
Předmět:
Zdroj: Phytochemistry
Phytochemistry, Elsevier, 1992, 31 (4), pp.1223-1233
ISSN: 0031-9422
DOI: 10.1016/0031-9422(92)80265-g
Popis: In the mycelium of all the Fusarium species studied, the major sterol was ergosterol in the absence of fenpropimorph. In the presence of this fungicide fenpropimorph-sensitive strains, with the exception of F. nivale , accumulated mainly Δ 8,14 -sterols and tolerant ones accumulated either both Δ 8,14 - and Δ 8 -sterols or only Δ 8 -sterols. This seemed to indicate that fenpropimorph toxicity was related to sterol Δ 14 -reductase sensitivity. In F. nivale , which was highly sensitive to fenpropimorph, the accumulation of only Δ 8 -sterols indicated that the main target enzyme was sterol Δ 8 →Δ 7 -isomerase. In addition to Δ 8,14 -and Δ 8 -sterols, squalene was accumulated in very high amounts in several strains; the level of squalene accumulation did not seem to be correlated with fenpropimorph sensitivity.
Databáze: OpenAIRE