One‑year oral toxicity study on a genetically modified maize MON810 variety in Wistar Han RCC rats (EU 7th Framework Programme project GRACE)
| Autor: | Nils Bohmer, Zora Krivošíková, Esther J. Kok, Christian Kohl, Miroslava Kuricova, Maria Pla, Pablo Steinberg, Viera Spustova, Dagmar Zeljenková, Gijs Kleter, Zuzana Ševčíková, Elena Szabova, A. Pöting, Marc Bohmer, Anton Kebis, Armin Spök, Ralf Einspanier, Júlia Ondrejková, Maria Corujo, Soňa Wimmerová, Radka Aláčová, Martin Cernak, Ralf Wilhelm, Karine Adel-Patient, Mikuláš Levkut, Jana Tulinska, Joachim Schiemann, Kerstin Schmidt, Eva Rollerova, Katarína Ambrušová, Paul Schmidt, Jevgenij Kovrižnych, Jörg Schmidtke, Maria Bartusova, Jutta Sharbati, Jose Luis La Paz, Aurelia Liskova, Viera Revajová |
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| Přispěvatelé: | Faculty of Public Health, Slovak Medical University of Bratislava (SMU), University of Veterinary Medicine and Pharmacy [Košice, Slovakia], GmbH, Center for Research in Agricultural Genomics, Universitat de Girona (UdG), Wageningen University and Research Centre (WUR), Free University of Berlin (FU), Service de Pharmacologie et d'Immunoanalyse (SPI), Institut National de la Recherche Agronomique (INRA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Inter-University Research Centre on Technology, Work and Culture, Partenaires INRAE, Bundesinstitut für Risikobewertung - Federal Institute for Risk Assessment (BfR), Julius Kühn-Institut (JKI), University of Veterinary Medicine Hannover, Department of Animal Nutrition, EU, Service de Pharmacologie et Immunoanalyse (SPI), Médicaments et Technologies pour la Santé (MTS), Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE)-Université Paris-Saclay-Direction de Recherche Fondamentale (CEA) (DRF (CEA)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE) |
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
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0301 basic medicine Novel Foods & Agrochains Health Status Health Toxicology and Mutagenesis [SDV]Life Sciences [q-bio] Food Genetically Modified Genetically modified crops Toxicology Novel Foods & Agroketens GRACE Rat feeding trial BU Toxicology Novel Foods & Agrochains Toxicity Tests Chronic Blat de moro -- Genètica 2. Zero hunger BU Toxicology 04 agricultural and veterinary sciences General Medicine Plants Genetically Modified 040401 food science Genetically modified organism OECD Test Guideline No. 452-Chronic toxicity studies (2009) Enginyeria genètica vegetal Food/Feed Guidance Document of the EFSA Scientific Committee (2011) BU Toxicologie Novel Foods & Agroketens Genetically modified maize MON810 OECD Test Guideline No. 452– Chronic toxicity studies (2009) Chronic oral toxicity study Female Risk assessment Plant genetic engineering Wistar Han Animal feed BU Toxicologie Biologics Biology Risk Assessment Zea mays 03 medical and health sciences Corn -- Genetics 0404 agricultural biotechnology OECD Test Guideline No. 452–Chronic toxicity studies (2009) Animals Adverse effect Genetically modified maize Plantes transgèniques business.industry Transgenic plants Rats Inbred Strains Guideline Animal Feed Biotechnology 030104 developmental biology business |
| Zdroj: | Archives of Toxicology Archives of Toxicology, Springer Verlag, 2016, 90 (10), ⟨10.1007/s00204-016-1798-4⟩ Recercat: Dipósit de la Recerca de Catalunya Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya) Archives of Toxicology, 90(10), 2531-2562 Archives of Toxicology, 2016, 90 (10), ⟨10.1007/s00204-016-1798-4⟩ Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona © Archives of Toxicology, 2016, vol. 90, núm. 10, p. 2531-2562 Articles publicats (D-EQATA) DUGiDocs – Universitat de Girona instname Recercat. Dipósit de la Recerca de Catalunya Archives of Toxicology 90 (2016) 10 Archives of Toxicology 10 (90), . (2016) |
| ISSN: | 0340-5761 1432-0738 |
| Popis: | The GRACE (GMO Risk Assessment and Communication of Evidence; www.grace-fp7.eu) project was funded by the European Commission within the 7th Framework Programme. A key objective of GRACE was to conduct 90-day animal feeding trials, animal studies with an extended time frame as well as analytical, in vitro and in silico studies on genetically modified (GM) maize in order to comparatively evaluate their use in GM plant risk assessment. In the present study, the results of a 1-year feeding trial with a GM maize MON810 variety, its near-isogenic non-GM comparator and an additional conventional maize variety are presented. The feeding trials were performed by taking into account the guidance for such studies published by the EFSA Scientific Committee in 2011 and the OECD Test Guideline 452. The results obtained show that the MON810 maize at a level of up to 33 % in the diet did not induce adverse effects in male and female Wistar Han RCC rats after a chronic exposure. Electronic supplementary material The online version of this article (doi:10.1007/s00204-016-1798-4) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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