Stereotactic radiosurgery results for brain metastasis patients with renal cancer: A validity study of Renal Graded Prognostic Assessment and proposal of a new grading index (JLGK2101 Study)
| Autor: | Toru Takebayashi, Yasunori Sato, Kiyoshi Nakasaki, Yoshinori Higuchi, Atsuya Akabane, Kyoko Aoyagi, Toru Serizawa, Masazumi Gondo, Jun Kawagishi, Rena Okuno-Ito, Takuya Kawabe, Takashi Shuto, Shoji Yomo, Yasuhiro Kikuchi, Masaaki Yamamoto |
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| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
medicine.medical_specialty
Test series medicine.medical_treatment R895-920 urologic and male genital diseases Radiosurgery Medical physics. Medical radiology. Nuclear medicine medicine Overall survival Prognostic grade Radiology Nuclear Medicine and imaging Original Research Article Grading (education) Stereotactic radiosurgery RC254-282 business.industry Cancer Neoplasms. Tumors. Oncology. Including cancer and carcinogens Brain metastases medicine.disease Confidence interval Renal cancer Oncology Radiology business Median survival Brain metastasis |
| Zdroj: | Clinical and Translational Radiation Oncology, Vol 32, Iss, Pp 69-75 (2022) Clinical and Translational Radiation Oncology |
| ISSN: | 2405-6308 |
| Popis: | Highlights • We performed a validity test of the Renal Graded Prognostic Assessment. • Therefore, we developed a new grading index. These results were validated using another dataset including 397 renal cancer patients with BMs. • This new grading system was clearly useful for predicting post-SRS outcomes of BM patients with renal cancer. Background and purpose The Renal Graded Prognostic Assessment (GPA) is relatively new and has not been sufficiently validated using a different dataset. We thus developed a new grading index, the Renal Brain Metastasis Score (Renal-BMS). Materials and methods Using our dataset including 262 renal cancer patients with brain metastases (BMs) undergoing stereotactic radiosurgery (SRS) (test series), we validity tested the Renal-GPA. Next, we applied clinical factor-survival analysis to the test series and thereby developed the Renal-BMS. This system was then validated using another series of 352 patients independently undergoing SRS at nine gamma knife facilities in Japan (verification series). Results Using the test series, with the Renal-GPA, 95% confidence intervals (CIs) of the post-SRS median survival times (MSTs) overlapped between pairs of neighboring subgroups. Among various pre-SRS clinical factors of the test series, six were highly associated with overall survival. Therefore, we assigned scores for six factors, i.e., “KPS ≥ 80%/ |
| Databáze: | OpenAIRE |
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