Induced Pluripotent Stem Cells as a Tool for Modeling Hematologic Disorders and as a Potential Source for Cell-Based Therapies
Autor: | Surapol Issaragrisil, Ponthip Pratumkaew, Sudjit Luanpitpong |
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Rok vydání: | 2021 |
Předmět: |
induced pluripotent stem cells
QH301-705.5 cell-based therapy Cellular differentiation medicine.medical_treatment Cell- and Tissue-Based Therapy Drug Evaluation Preclinical Review Disease Computational biology Models Biological Regenerative medicine Cancer immunotherapy disease modeling medicine Animals Humans blood disorders genetic disorders Biology (General) Progenitor cell Induced pluripotent stem cell business.industry Drug discovery General Medicine medicine.disease Hematologic Diseases Hematopoiesis Hematologic disease business |
Zdroj: | Cells, Vol 10, Iss 3250, p 3250 (2021) Cells |
ISSN: | 2073-4409 |
Popis: | The breakthrough in human induced pluripotent stem cells (hiPSCs) has revolutionized the field of biomedical and pharmaceutical research and opened up vast opportunities for drug discovery and regenerative medicine, especially when combined with gene-editing technology. Numerous healthy and patient-derived hiPSCs for human disease modeling have been established, enabling mechanistic studies of pathogenesis, platforms for preclinical drug screening, and the development of novel therapeutic targets/approaches. Additionally, hiPSCs hold great promise for cell-based therapy, serving as an attractive cell source for generating stem/progenitor cells or functional differentiated cells for degenerative diseases, due to their unlimited proliferative capacity, pluripotency, and ethical acceptability. In this review, we provide an overview of hiPSCs and their utility in the study of hematologic disorders through hematopoietic differentiation. We highlight recent hereditary and acquired genetic hematologic disease modeling with patient-specific iPSCs, and discuss their applications as instrumental drug screening tools. The clinical applications of hiPSCs in cell-based therapy, including the next-generation cancer immunotherapy, are provided. Lastly, we discuss the current challenges that need to be addressed to fulfill the validity of hiPSC-based disease modeling and future perspectives of hiPSCs in the field of hematology. |
Databáze: | OpenAIRE |
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