Differential vasorelaxant effects of levcromakalim and P1060 in the isolated KCl- and RbCl-precontracted human saphenous vein: possible involvement of intracellular Ca2+ stores
| Autor: | Roberto Soares de Moura, Waldir Jazbik, David N. Criddle |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Cromakalim
Potassium Channels Contraction (grammar) Nifedipine Vasodilator Agents chemistry.chemical_element In Vitro Techniques Calcium Pharmacology Guanidines Potassium Chloride Norepinephrine chemistry.chemical_compound Chlorides Caffeine medicine Humans Benzopyrans Pyrroles Saphenous Vein Biological activity Rubidium eye diseases stomatognathic diseases Electrophysiology medicine.anatomical_structure Mechanism of action chemistry Anesthesia medicine.symptom Intracellular Blood vessel |
| Zdroj: | European Journal of Pharmacology. 286:123-130 |
| ISSN: | 0014-2999 |
| DOI: | 10.1016/0014-2999(95)00426-l |
| Popis: | The influence of rubidium-substituted physiological salt solution (Rb-PSS) on the relaxant effects of K+ channel openers was investigated in the human saphenous vein. In tissues precontracted with 20 mM KCl (in K-PSS) levcromakalim and P1060 produced complete, sustained relaxations. However, in Rb-PSS (containing 20 mM RbCl) these effects were inhibited and, although complete relaxations still occurred, were transient. When caffeine was applied at the beginning of this fade of levcromakalim-induced relaxation in Rb-PSS its contractile effect was potentiated. Similarly, the contraction to noradrenaline was potentiated when applied at the beginning of this fade of levcromakalim-induced relaxation, whereas this response was attenuated in control tissues bathed in 20 mM KCl (in K-PSS). Our results show that the relaxant effects of K+ channel openers in human saphenous vein are inhibited in Rb-PSS, in agreement with previous studies in animal tissue, and suggest that an increased Ca2+ uptake into intracellular stores may be contributory to vasorelaxation. |
| Databáze: | OpenAIRE |
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