3T magnetic resonance spectroscopy as a powerful diagnostic modality for assessment of thyroid nodules

Autor: Soheil Kooraki, Pirouz Pirouzi, Nasrin Yazdani, Hashem Sharifian, Leila Aghaghazvini, Afsoon Ghadiri, Majid Assadi
Jazyk: angličtina
Předmět:
Thyroid nodules
Adult
Male
medicine.medical_specialty
Endocrinology
Diabetes and Metabolism
Proton Magnetic Resonance Spectroscopy
lcsh:Medicine
Sensitivity and Specificity
lcsh:Diseases of the endocrine glands. Clinical endocrinology
Statistics
Nonparametric
030218 nuclear medicine & medical imaging
Thyroid carcinoma
03 medical and health sciences
Young Adult
0302 clinical medicine
Reference Values
choline
Magnetic resonance spectroscopy
Medicine
Humans
Clinical significance
Prospective Studies
Thyroid Neoplasms
Thyroid Nodule
Prospective cohort study
lcsh:RC648-665
Receiver operating characteristic
business.industry
thyroid nodules
Thyroid
Carcinoma
lcsh:R
Reproducibility of Results
Nodule (medicine)
Middle Aged
medicine.disease
Creatine
thyroid carcinoma
medicine.anatomical_structure
Histopathology
Female
medicine.symptom
business
Nuclear medicine
030217 neurology & neurosurgery
Zdroj: Archives of Endocrinology and Metabolism, Vol 62, Iss 5, Pp 501-505
Archives of Endocrinology and Metabolism v.62 n.5 2018
Arquivos de Endocrinologia e Metabolismo
Sociedade Brasileira de Endocrinologia e Metabologia (SBEM)
instacron:SBEM
ISSN: 2359-4292
Popis: Objective: Magnetic resonance spectroscopy (MRS) is a powerful tool for structural studies of chemical compounds and biomolecules and also documented promising findings as a potential imaging technology in thyroid oncology. This prospective study was to ascertain the clinical significance of 3 Tesla MRS in the evaluation of patients with thyroid nodules (TNs) as an ancillary diagnostic technique for thyroid carcinoma. Materials and methods: Magnetic resonance spectroscopy at 3T at echo- times (TEs) 136 and 270 ms was carried out on 15 patients with total number of 32 TNs larger than 1 cm3, which all were surgically resected. Choline (Chol) to creatine (Cr) ratio was assessed at 136 and 270 TEs on each nodule and a receiver operating characteristic (ROC) curve was used to determine optimal cut-off point. The findings were compared with histopathology of thyroid specimens. Results: There were 23 benign and 9 malignant lesions (7 papillary and 2 follicular thyroid carcinomas). The mean values of Chol/Cr at 136 and 270 TEs was 2.28 ± 3.65 and 1.52 ± 1.67 respectively and the difference between benign and malignant nodules was only significant at 136 TEs. The study revealed that Chol/ Cr ratio cut-off point of 2.5 best correlates with histopathology results (sensitivity = 75%; specificity = 100%; PPV = 100%; NPV= 92%). Conclusion: This preliminary study showed that 3T magnetic resonance spectroscopy might be a specific modality for the evaluation of thyroid nodules in differentiation of benign from malignant thyroid tissue. However, a larger series would give much greater confidence that this state-of-the-art technology will worth pursuing in clinical practice.
Databáze: OpenAIRE
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