Role of smooth muscle cells in Cardiovascular Disease
| Autor: | Chang Jia, Jian Zhang, Xing Rong, Yingzhi Zhuge, Ke Xu, Maoping Chu, Zhengwang Wen, Hao Ji, Chao Niu, Fanyu Qian |
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| Rok vydání: | 2020 |
| Předmět: |
Tunica media
Cell type Pathology medicine.medical_specialty Cell Plasticity Myocytes Smooth Muscle Review Disease phenotype switching Applied Microbiology and Biotechnology Epigenesis Genetic Extracellular matrix 03 medical and health sciences cardiovascular disease arterial aneurysms medicine Animals Humans Myocardial infarction Molecular Biology Pathological Ecology Evolution Behavior and Systematics 030304 developmental biology 0303 health sciences business.industry Muscle Smooth Cell Biology musculoskeletal system medicine.disease Phenotype smooth muscle cells medicine.anatomical_structure Cardiovascular Diseases cardiovascular system Female business tissues Developmental Biology Artery |
| Zdroj: | International Journal of Biological Sciences |
| ISSN: | 1449-2288 |
| Popis: | Normally, smooth muscle cells (SMCs) are localized in the tunica media of the vasculature, where they take responsibility for vascular contraction and extracellular matrix (ECM) generation. SMCs also play a significant role in obedience and elastic rebound of the artery in response to the haemodynamic condition. However, under pathological or stressed conditions, phenotype switching from contractile to synthetic state or other cell types will occur in SMCs to positively or negatively contribute to disease progression. Various studies demonstrated that functional changes of SMCs are implicated in several cardiovascular diseases. In this review, we present the function of vascular SMCs (VSMCs) and the involved molecular mechanisms about phenotype switching, and summarize the roles of SMCs in atherosclerosis, hypertension, arterial aneurysms and myocardial infarction, hoping to obtain potential therapeutic targets against cardiovascular disease in the clinical practices. |
| Databáze: | OpenAIRE |
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