Haploidentical transplantation outcomes are comparable with those obtained with identical human leukocyte antigen allogeneic transplantation in Chilean patients with benign and malignant hemopathies
| Autor: | Isabel Leiva Rodríguez, Mauricio Galleguillos, Carla Lorca, Veronica Jara, Elizabeth Rivera, Mauricio Ocqueteau, Mauricio Sarmiento, Pablo Ramirez, Isabel Pizarro, Pablo Bertin |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
Allogeneic transplantation Lymphoma Cyclophosphamide Platelet Engraftment Haploidentical transplantation Human leukocyte antigen 030204 cardiovascular system & hematology Gastroenterology Umbilical cord 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Immunology and Allergy Cumulative incidence Leukemia lcsh:RC633-647.5 business.industry lcsh:Diseases of the blood and blood-forming organs Hematology medicine.disease Transplantation medicine.anatomical_structure Original Article business 030215 immunology medicine.drug |
| Zdroj: | Hematology, Transfusion and Cell Therapy, Volume: 42, Issue: 1, Pages: 40-45, Published: 30 MAR 2020 Hematology, Transfusion and Cell Therapy Hematology, Transfusion and Cell Therapy, Vol 42, Iss 1, Pp 40-45 (2020) |
| ISSN: | 2531-1379 |
| Popis: | Introduction: Patients with benign or malignant blood disorders, who require allogeneic stem cell transplantation and lack an identical human leukocyte antigen HLA identicalHL sibling donor, could be transplanted with hematopoietic stem cells from unrelated adult or umbilical cord donors. However, in our country, both approaches are costly and time-consuming options. Methods: Over the last few years, haploidentical modalities have been investigated as an alternative donor source, showing similar results to those obtained with identical HLA donors. We started using T-cell-replete haploidentical with post-transplant cyclophosphamide in 2012 and we presented our experience with patients undergoing haploidentical ransplantation compared to SIB. Results: Since January 2012 to date, 91 allogeneic transplants have been performed, of which 49 were haploidentical and 42 were HLA identical. The mean age of the patients was 35 years (range: 17–62). The mean CD34/kg × 106 infused per group was 5.93 and 5.89, respectively. Time to granulocyte and platelet engraftment was 11 and 15 days, respectively, for haploidentical, and 12 and 14 days, respectively, for HLA identical (p = 0.10). The 100-day cumulative incidence of global acute GVHD was 34% for haploidentical and 29% for SIHLA identical (p = 0.9). The 2-year overall global graft-versus-host disease was 43% for haploidentical and 41% for HLA identical (p = 0.8). Overall survival, relapse, and transplant and relapse-related mortality were similar between both groups. Conclusion: Our experience showed that haploidentical has similar outcomes to those obtained with HLA idential and can be performed in our country safely. Keywords: Leukemia, Lymphoma, Haploidentical transplantation |
| Databáze: | OpenAIRE |
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