Parenchymal cystatin C focal deposits and glial scar formation around brain arteries in Hereditary Cystatin C Amyloid Angiopathy
| Autor: | Birkir Thor Bragason, Stephan A. Kaeser, Elias Olafsson, Helgi J Isaksson, Angelos Skodras, Astridur Palsdottir, Asbjorg Osk Snorradottir |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Male
Pathology metabolism [Antigens CD] Cerebral arteries metabolism [Arterioles] pathology [Arterioles] CD68 antigen human pathology [Brain] genetics [Cerebral Amyloid Angiopathy Familial] metabolism [Cicatrix] AIF1 protein human Glial fibrillary acidic protein biology General Neuroscience Microfilament Proteins Brain Anatomy Middle Aged genetics [Cystatin C] DNA-Binding Proteins Arterioles CST3 protein human medicine.anatomical_structure Female metabolism [DNA-Binding Proteins] Neuroglia Brain Infarction Adult pathology [Cicatrix] medicine.medical_specialty Amyloid Neuroimmunomodulation physiology [Neuroimmunomodulation] Antigens Differentiation Myelomonocytic physiopathology [Cerebral Amyloid Angiopathy Familial] Glial scar White matter blood supply [Brain] Cicatrix Young Adult physiopathology [Brain Infarction] Antigens CD Parenchyma Glial Fibrillary Acidic Protein medicine Humans pathology [Cerebral Arteries] ddc:610 Cystatin C Molecular Biology Aged pathology [Neuroglia] Calcium-Binding Proteins pathology [Brain Infarction] metabolism [Glial Fibrillary Acidic Protein] pathology [Cerebral Amyloid Angiopathy Familial] Cerebral Arteries Hereditary cystatin C amyloid angiopathy metabolism [Antigens Differentiation Myelomonocytic] metabolism [Brain] biology.protein metabolism [Cystatin C] Neurology (clinical) Developmental Biology Cerebral Amyloid Angiopathy Familial |
| Zdroj: | Brain research 1622, 149-162 (2015). doi:10.1016/j.brainres.2015.06.019 |
| DOI: | 10.1016/j.brainres.2015.06.019 |
| Popis: | Hereditary Cystatin C Amyloid Angiopathy (HCCAA) is an amyloid disorder in Icelandic families caused by an autosomal dominant mutation in the cystatin C gene. Mutant cystatin C forms amyloid deposits in brain arteries and arterioles which are associated with changes in the arterial wall structure, notably deposition of extracellular matrix proteins. In this post-mortem study we examined the neuroinflammatory response relative to the topographical distribution of cystatin C deposition, and associated haemorrhages, in the leptomeninges, cerebrum, cerebellum, thalamus, and midbrain of HCCAA patients. Cystatin C was deposited in all brain areas, grey and white matter alike, most prominently in arteries and arterioles; capillaries and veins were not, or minimally, affected. We also observed perivascular deposits and parenchymal focal deposits proximal to affected arteries. This study shows for the first time, that cystatin C does not exclusively form CAA and perivascular amyloid but also focal deposits in the brain parenchyma. Haemorrhages were observed in all patients and occurred in all brain areas, variable between patients. Microinfarcts were observed in 34.6% of patients. The neuroinflammatory response was limited to the close vicinity of affected arteries and perivascular as well as parenchymal focal deposits. Taken together with previously reported arterial accumulation of extracellular matrix proteins in HCCAA, our results indicate that the central nervous system pathology of HCCAA is characterised by the formation of a glial scar within and around affected arteries. |
| Databáze: | OpenAIRE |
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