C-Reactive Protein and Cognition Are Unrelated to Leukoaraiosis
| Autor: | Emílio Hideyuki Moriguchi, Paulo Dornelles Picon, Matheus Roriz-Cruz, Idiane Rosset, Fabricio Correia Marques, Marcia Lorena Fagundes Chaves, Liara Rizzi |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
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medicine.medical_specialty Article Subject Population lcsh:Medicine behavioral disciplines and activities Gastroenterology lcsh:Technology General Biochemistry Genetics and Molecular Biology Elevated serum Cognition Internal medicine medicine Humans education Cognitive impairment lcsh:Science Proteina C-reativa Aged General Environmental Science education.field_of_study biology business.industry lcsh:T C-reactive protein lcsh:R Leukoaraiosis Leucoaraiose General Medicine Middle Aged Surgery C-Reactive Protein Increased risk biology.protein Female lcsh:Q Cognition Disorders business Cognição Research Article |
| Zdroj: | The Scientific World Journal, Vol 2014 (2014) Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS The Scientific World Journal |
| ISSN: | 2356-6140 |
| Popis: | Elevated serum levels of C-reactive protein (CRP) have been associated with leukoaraiosis in elderly brain. However, several studies indicate that leukoaraiosis is associated with an increased risk of cognitive impairment. It is unknown how the effect of CRP on cognition is mediated by leukoaraiosis. The purpose of this study is to assess the relationship between serum levels of CRP, the presence of leukoaraiosis, and cognitive impairment in a population of coronary patients over 50 years old. CRP levels explained 7.18% (P: 0.002) of the variance of the MMSE. The adjustment for the presence of leukoaraiosis little changed this variance (5.98%,P: 0.005), indicating that only a small portion of the CRP influence on cognition was mediated via leukoaraiosis. Patients with CRP levels ≥5.0 had 2.9 (95% CI: 1.26–6.44) times more chance to present cognitive impairment (P: 0.012). We found that elevated serum levels of CRP were associated with increased risk of cognitive impairment in elderly and it was not mediated by presence of leukoaraiosis. |
| Databáze: | OpenAIRE |
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