Pharmacokinetics in nonhuman primates of a prototype carbapenem active against methicillin-resistant Staphylococcus aureus
| Autor: | R Thompson, L Cama, Jon G. Sundelof, M W Sasor, K M White, Helmut Kropp |
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| Rok vydání: | 1996 |
| Předmět: |
Male
Imipenem Carbapenem Dipeptidases Staphylococcus aureus Pan troglodytes medicine.drug_class Antibiotics Cilastatin Imipenem Drug Combination Pharmacology medicine.disease_cause Kidney Pharmacokinetics medicine polycyclic compounds Animals Pharmacology (medical) Antibacterial agent Cilastatin business.industry Imidazoles Methicillin-resistant Staphylococcus aureus Macaca mulatta Anti-Bacterial Agents Drug Combinations Infectious Diseases Carbapenems Injections Intravenous Drug Therapy Combination Methicillin Resistance business medicine.drug Half-Life Research Article |
| Zdroj: | Antimicrobial agents and chemotherapy. 40(3) |
| ISSN: | 0066-4804 |
| Popis: | Pharmacokinetic parameters were determined for imipenem-cilastatin and a carbapenem antibiotic, L-695,256, active against methicillin-resistant Staphylococcus aureus in rhesus monkeys and a chimpanzee. L-695,256 had larger areas under the concentration-time curve than imipenem-cilastatin (30 +/- 5 versus 24 +/- 1 micrograms.h/ml in the rhesus monkeys and 77 versus 60 micrograms.h/ml in the chimpanzee) and a longer half-life at beta phase (1.2 +/- 0.1 versus 0.6 +/- 0.1 h in the rhesus monkeys and 1.0 versus 0.8 h in the chimpanzee). Resistance to hydrolysis by the renal dehydropeptidase-I allowed L-695,256 to be administered as a single agent. |
| Databáze: | OpenAIRE |
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