Twenty-year trends in the prevalence of Down syndrome and other trisomies in Europe : impact of maternal age and prenatal screening
| Autor: | Catherine Rounding, Judith L. S. Budd, Maria Loane, Bob McDonnell, Ester Garne, Babak Khoshnood, Larraitz Arriola, Marie-Claude Addor, Kari Klungsøyr Melve, Diana Wellesley, Joaquin Salvador, Carmel Mullaney, Helen Dolk, Annette Queißer-Wahrendorf, Anna Latos-Bielenska, Lyubov Yevtushok, Bérénice Doray, David Tucker, Judith Rankin, Miriam Gatt, Joan K. Morris, Martin Haeusler, Mary O'Mahony, Anke Rissmann |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Trisomy
Abortion Pregnancy Prenatal Diagnosis Down Syndrome/diagnosis Medicine trisomy 18 Registries trisomy 13 Genetics (clinical) Genetics education.field_of_study Obstetrics Pregnancy Outcome Down syndrome -- Case studies Gestational age Europe trisomy 21 Fetal Death/epidemiology Female Live birth Live Birth Maternal Age trends Adult medicine.medical_specialty Down syndrome Medical screening Population Prenatal diagnosis Article Pregnancy Outcome/epidemiology Europe/epidemiology Age Distribution Humans education Fetal Death Maternal age Chromosomes Human Pair 13 business.industry Abortion Induced medicine.disease Trisomy/diagnosis Live Birth/epidemiology prenatal screening Trisomy -- Patients -- Care Down Syndrome business Chromosomes Human Pair 18 Abortion Induced/statistics & numerical data |
| Zdroj: | Loane, M, Morris, J K, Addor, M-C, Arriola, L, Budd, J, Doray, B, Garne, E, Gatt, M, Haeusler, M, Khoshnood, B, Klungsøyr Melve, K, Latos-Bielenska, A, McDonnell, B, Mullaney, C, O'Mahony, M, Queißer-Wahrendorf, A, Rankin, J, Rissmann, A, Rounding, C, Salvador, J, Tucker, D, Wellesley, D, Yevtushok, L & Dolk, H 2013, ' Twenty-year trends in the prevalence of Down syndrome and other trisomies in Europe : impact of maternal age and prenatal screening ', European Journal of Human Genetics, vol. 21, pp. 27-33 . https://doi.org/10.1038/ejhg.2012.94 EUROPEAN JOURNAL OF HUMAN GENETICS r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname |
| ISSN: | 1018-4813 |
| DOI: | 10.1038/ejhg.2012.94 |
| Popis: | This study examines trends and geographical differences in total and live birth prevalence of trisomies 21, 18 and 13 with regard to increasing maternal age and prenatal diagnosis in Europe. Twenty-one population-based EUROCAT registries covering 6.1 million births between 1990 and 2009 participated. Trisomy cases included live births, fetal deaths from 20 weeks gestational age and terminations of pregnancy for fetal anomaly. We present correction to 20 weeks gestational age (ie, correcting early terminations for the probability of fetal survival to 20 weeks) to allow for artefactual screening-related differences in total prevalence. Poisson regression was used. The proportion of births in the population to mothers aged 35 þ years in the participating registries increased from 13% in 1990 to 19% in 2009. Total prevalence per 10 000 births was 22.0 (95% CI 21.7–22.4) for trisomy 21, 5.0 (95% CI 4.8–5.1) for trisomy 18 and 2.0 (95% CI 1.9–2.2) for trisomy 13; live birth prevalence was 11.2 (95% CI 10.9–11.5) for trisomy 21, 1.04 (95% CI 0.96–1.12) for trisomy 18 and 0.48 (95% CI 0.43–0.54) for trisomy 13. There was an increase in total and total corrected prevalence of all three trisomies over time, mainly explained by increasing maternal age. Live birth prevalence remained stable over time. For trisomy 21, there was a three-fold variation in live birth prevalence between countries. The rise in maternal age has led to an increase in the number of trisomy-affected pregnancies in Europe. Live birth prevalence has remained stable overall. Differences in prenatal screening and termination between countries lead to wide variation in live birth prevalence. peer-reviewed |
| Databáze: | OpenAIRE |
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