Quantification of global myocardial oxygenation in humans: initial experience

Autor: Jie Zheng, Robert D. O'Connor, Pamela K. Woodard, Robert J. Gropler, Matt Lyons, Donna Lesniak, Kyle S. McCommis
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Adult
Male
medicine.medical_specialty
lcsh:Diseases of the circulatory (Cardiovascular) system
Adenosine
Time Factors
Technical notes
Vasodilator Agents
Blood Pressure
Hyperemia
Perfusion scanning
030218 nuclear medicine & medical imaging
03 medical and health sciences
Coronary circulation
Oxygen Consumption
0302 clinical medicine
Heart Rate
Predictive Value of Tests
Coronary Circulation
Internal medicine
Heart rate
medicine
Humans
Radiology
Nuclear Medicine and imaging
Oximetry
Coronary sinus
Angiology
Medicine(all)
Radiological and Ultrasound Technology
medicine.diagnostic_test
Phantoms
Imaging
business.industry
Myocardium
Models
Cardiovascular
Magnetic resonance imaging
Oxygenation
Blood flow
Magnetic Resonance Imaging
Oxygen
medicine.anatomical_structure
lcsh:RC666-701
Cardiology
Feasibility Studies
Female
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Zdroj: Journal of Cardiovascular Magnetic Resonance, Vol 12, Iss 1, p 34 (2010)
Journal of Cardiovascular Magnetic Resonance
ISSN: 1097-6647
Popis: Purpose To assess the feasibility of our newly developed cardiovascular magnetic resonance (CMR) methods to quantify global and/or regional myocardial oxygen consumption rate (MVO2) at rest and during pharmacologically-induced vasodilation in normal volunteers. Methods A breath-hold T2 quantification method is developed to calculate oxygen extraction fraction (OEF) and MVO2 rate at rest and/or during hyperemia, using a two-compartment model. A previously reported T2 quantification method using turbo-spin-echo sequence was also applied for comparison. CMR scans were performed in 6 normal volunteers. Each imaging session consisted of imaging at rest and during adenosine-induced vasodilation. The new T2 quantification method was applied to calculate T2 in the coronary sinus (CS), as well as in myocardial tissue. Resting CS OEF, representing resting global myocardial OEF, and myocardial OEF during adenosine vasodilation were then calculated by the model. Myocardial blood flow (MBF) was also obtained to calculate MVO2, by using a first-pass perfusion imaging approach. Results The T2 quantification method yielded a hyperemic OEF of 0.37 ± 0.05 and a hyperemic MVO2 of 9.2 ± 2.4 μmol/g/min. The corresponding resting values were 0.73 ± 0.05 and 5.2 ± 1.7 μmol/g/min respectively, which agreed well with published literature values. The MVO2 rose proportionally with rate-pressure product from the rest condition. The T2 sensitivity is approximately 95% higher with the new T2 method than turbo-spin-echo method. Conclusion The CMR oxygenation method demonstrates the potential for non-invasive estimation of myocardial oxygenation, and should be explored in patients with altered myocardial oxygenation.
Databáze: OpenAIRE
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