Haplotypes in BMP4 and FGF Genes Increase the Risk of Peri-Implantitis
| Autor: | José Mauro Granjeiro, Quinelato, Rackel Gonçalves, Letícia Ladeira Bonato, Villas-Boas Rde M, Pinheiro Ada R, Carlos Henrique Ramirez Nunes, Coelho Rb, Priscila Ladeira Casado, Alexandre R. Vieira, Aldir Nascimento Machado, Gonçalves R Junior |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Bone Morphogenetic Protein 4 Biology Bone morphogenetic protein 03 medical and health sciences 0302 clinical medicine Double-Blind Method Polymorphism (computer science) Internal medicine Genotype medicine Humans Genetic Predisposition to Disease Allele Bone regeneration General Dentistry Fibroblast growth factor receptor 1 Haplotype Infant 030206 dentistry Middle Aged Peri-Implantitis Phenotype Fibroblast Growth Factors stomatognathic diseases Cross-Sectional Studies 030104 developmental biology Endocrinology Haplotypes Immunology Female |
| Zdroj: | Brazilian Dental Journal. 27:367-374 |
| ISSN: | 0103-6440 |
| Popis: | Despite the success of osseointegrated implants, failures have increased significantly, associated with development of peri-implantitis. Multiple factors influence the peri-implant bone loss, including environmental and genetic causes. BMPs (Bone morphogenetic proteins) are growth factors that induce bone formation. FGF (fibroblast growth factors) and their receptors (FGFRs) play important roles by controlling the levels of cell proliferation, differentiation and migration. BMP/FGF relationship is responsible for promoting bone regeneration and bone loss. The aim of this study was to analyze the correlation between BMP4, FGF3, FGF10 and FGFR1 genes and peri-implant bone loss. Two hundred and fifteen volunteers, with 754 dental implants, were submitted to oral examination and divided in healthy group (n=129) and peri-implantitis group (n=86). Thirteen polymorphisms in BMP4, FGF3, FGF10 and FGFR1 genes were analyzed individually and in haplotype. The chi-square test correlated genotypes, allelic and haplotype frequencies. Values of p |
| Databáze: | OpenAIRE |
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