Molecular and Cellular Mechanisms of Vascular Development in Zebrafish
| Autor: | Julian Malchow, Jean Eberlein, Christian S. M. Helker, Lukas Herdt, Annegret Rittershaus, Stefan Baumeister |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
animal structures
Angiogenesis Science ved/biology.organism_classification_rank.species Danio Review Vegf General Biochemistry Genetics and Molecular Biology vasculogenesis blood vessels angiogenesis Vasculogenesis medicine Model organism Zebrafish Ecology Evolution Behavior and Systematics biology ved/biology Paleontology Embryo biology.organism_classification zebrafish endothelial cells signaling pathways Cell biology medicine.anatomical_structure Space and Planetary Science Apelin Signal transduction Blood vessel |
| Zdroj: | Life Life, Vol 11, Iss 1088, p 1088 (2021) |
| ISSN: | 2075-1729 |
| Popis: | The establishment of a functional cardiovascular system is crucial for the development of all vertebrates. Defects in the development of the cardiovascular system lead to cardiovascular diseases, which are among the top 10 causes of death worldwide. However, we are just beginning to understand which signaling pathways guide blood vessel growth in different tissues and organs. The advantages of the model organism zebrafish (Danio rerio) helped to identify novel cellular and molecular mechanisms of vascular growth. In this review we will discuss the current knowledge of vasculogenesis and angiogenesis in the zebrafish embryo. In particular, we describe the molecular mechanisms that contribute to the formation of blood vessels in different vascular beds within the embryo. |
| Databáze: | OpenAIRE |
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