Obesity, sedentary lifestyle, and exhaled nitric oxide in an early adolescent cohort
| Autor: | Emily Oken, Thomas J. Platts‐Mills, Mary B. Rice, Diane R. Gold, Bess M. Flashner, Lisa J. Workman, Sheryl L. Rifas-Shiman, Carlos A. Camargo, Augusto A. Litonjua |
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| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
Male medicine.medical_specialty Adolescent Overweight Nitric Oxide Body fat percentage Article Body Mass Index Cohort Studies 03 medical and health sciences 0302 clinical medicine Thinness 030225 pediatrics Internal medicine Hypersensitivity Medicine Humans Obesity Child Sedentary lifestyle Inflammation business.industry respiratory system medicine.disease Asthma respiratory tract diseases 030228 respiratory system Adipose Tissue Exhalation Pediatrics Perinatology and Child Health Exhaled nitric oxide Cohort Female Underweight medicine.symptom Sedentary Behavior Waist Circumference business Body mass index Biomarkers |
| Zdroj: | Pediatr Pulmonol |
| ISSN: | 1099-0496 |
| Popis: | Fractional exhaled nitric oxide (FeNO) is a marker of airway inflammation that is well-characterized in allergic disease states. However, FeNO is also involved in nonallergic inflammatory and pulmonary vascular mechanisms or responses to environmental stimuli. We sought to determine the extent to which obesity or sedentary lifestyle is associated with FeNO in adolescents not selected on the basis of allergic disease. In Project Viva, a prebirth cohort study, we measured body mass index (BMI), skinfold thicknesses, waist circumference, body fat, hours watching television, hours of physical activity, and heart rate after exercise among 929 adolescents (median age, 12.9). We measured FeNO twice and averaged these as a continuous, log-transformed outcome. We performed linear regression models, adjusted for child age, sex, height, and race/ethnicity, maternal education and smoking during pregnancy, household income and smoking, and neighbourhood characteristics. In secondary analysis, we additionally adjusted for asthma. More than 2 hours spent watching TV was associated with 10% lower FeNO (95% confidence interval [CI]: -20, 0%). Higher body fat percentage was also associated with lower FeNO. After additional adjustment for asthma, teens who are underweight (BMI |
| Databáze: | OpenAIRE |
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