Anaerobic Origin of Ergothioneine
| Autor: | Laëtitia Misson, Reto Burn, Marcel Meury, Florian P. Seebeck |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Metabolite Microorganism chemistry.chemical_element Chlorobium 01 natural sciences Catalysis Article chemistry.chemical_compound 03 medical and health sciences Biosynthesis Bacterial Proteins Anaerobiosis chemistry.chemical_classification Reactive oxygen species biology Chemistry 010405 organic chemistry Ergothioneine General Chemistry General Medicine biology.organism_classification Sulfur Biosynthetic Pathways 0104 chemical sciences Oxygen Enzyme 030104 developmental biology Biochemistry Bacteria |
| Zdroj: | Angewandte Chemie. 129:12682-12685 |
| ISSN: | 1521-3757 0044-8249 |
| Popis: | Ergothioneine is a sulfur metabolite that occurs in microorganisms, fungi, plants, and animals. The physiological function of ergothioneine is not clear. In recent years broad scientific consensus has formed around the idea that cellular ergothioneine primarily protects against reactive oxygen species. Herein we provide evidence that this focus on oxygen chemistry may be too narrow. We describe two enzymes from the strictly anaerobic green sulfur bacterium Chlorobium limicola that mediate oxygen-independent biosynthesis of ergothioneine. This anoxic origin suggests that ergothioneine is also important for oxygen-independent life. Furthermore, one of the discovered ergothioneine biosynthetic enzymes provides the first example of a rhodanese-like enzyme that transfers sulfur to non-activated carbon. |
| Databáze: | OpenAIRE |
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