Acute pancreatitis, bacterial translocation, and different octreotide regimens: An experimental study
Autor: | Atilla Akova, Muzaffer Caydere, Istar Dolapci, Erol Kisli, Saadet Akturan, Osman Güler |
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Rok vydání: | 2009 |
Předmět: |
Male
medicine.medical_specialty Octreotide Bacterial translocation Polymerase Chain Reaction Gastroenterology Adjuvants Immunologic Gastrointestinal Agents Ileum Surgical oncology Internal medicine medicine Animals Rats Wistar Misoprostol business.industry General Medicine Levamisole medicine.disease Rats Zinc Treatment Outcome Pancreatitis Bacterial Translocation Acute Disease Immunology Acute pancreatitis Drug Therapy Combination Surgery business medicine.drug |
Zdroj: | Surgery Today. 39:876-883 |
ISSN: | 1436-2813 0941-1291 |
Popis: | To determine the effect of octreotide, octreotide with zinc, levamisole, and misoprostol on the bacterial translocation that develops in rats with acute pancreatitis (AP).A total of 36 rats were divided into six groups, each consisting of six rats. Only laparotomy was performed on the first group. Acute pancreatitis was performed on the second group. Octreotide was given to the third, fourth, fifth, and sixth groups. Octreotide, octreotide with zinc, levamisole, and misoprostol were given to groups III, IV, V, VI, respectively. Rats were euthanized 48 h after the occurrence of AP. Blood and mesenteric lymph node samples were collected for polymerase chain reaction (PCR). Pancreatic tissue and terminal ileum were obtained for histopathological examinations.The severity of pancreatitis and mucosal damage of the terminal ileum was higher in group II than groups I, III, IV, V, and VI, histopathologically (P0.05). There wasn't a significant difference with respect to OA with Zn or L or M and OA group (P0.05). A significant difference was found in PCR positivity in blood and mesenteric lymph node between groups I and II (P0.05).In AP, administering octreotide alone significantly prevented the bacterial translocation by preventing mucosal damage. The zinc, levamisole, or misoprostol with octreotide did not influence the results. |
Databáze: | OpenAIRE |
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