Primary post‐transplant lymphoproliferative disorder of the central nervous system: characteristics, management and outcome in 25 paediatric patients
| Autor: | Anna Füreder, Jelena Lazic, Alan K. S. Chiang, Simon Bomken, Veronique Minard-Colin, Andishe Attarbaschi, Anne Uyttebroeck, Suzanne D. Turner, Rebecca Ling, Stéphanie Haouy, Birgit Burkhardt, Monika Csóka, Natalia Miakova, Mary Taj, Britta Maecker-Kolhoff |
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| Přispěvatelé: | Burkhardt, Birgit [0000-0002-1151-829X], Chiang, Alan KS [0000-0002-1089-5325], Turner, Suzanne D [0000-0002-8439-4507], Attarbaschi, Andishe [0000-0002-9285-6898], Apollo - University of Cambridge Repository |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Central nervous system post-transplant lymphoproliferative disorder Disease Gastroenterology Disease-Free Survival Post-transplant lymphoproliferative disorder 03 medical and health sciences 0302 clinical medicine hemic and lymphatic diseases Internal medicine medicine Humans transplant Child Injections Spinal Kidney treatment Brain Neoplasms business.industry Hematopoietic Stem Cell Transplantation Infant Organ Transplantation Hematology central nervous system Allografts medicine.disease Lymphoproliferative Disorders 3. Good health Lymphoma Survival Rate Haematopoiesis medicine.anatomical_structure Child Preschool 030220 oncology & carcinogenesis outcome Female Rituximab Stem cell business 030215 immunology medicine.drug |
| Zdroj: | British Journal of Haematology. 193:1178-1184 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/bjh.17398 |
| Popis: | Primary central nervous system (CNS) post-transplant lymphoproliferative disorder (PTLD) in childhood is rare. Twenty-five patients were retrieved from nine European Intergroup for Childhood Non-Hodgkin's Lymphoma and/or international Berlin-Frankfurt-Münster Study Group members. Types of allografts included kidney (n = 11), liver (n = 4), heart (n = 5), bowel (n = 1) and haematopoietic stem cells (n = 4). Eighteen were male, 16 ≥ 10 years old, 21 had monomorphic disease and 24 solid intracranial tumour masses. Four-year event-free and overall survival rates were 50% ± 10% and 74% ± 9% respectively. This report represents the largest paediatric series of CNS PTLD reported to date, showing favourable survival odds following systemic and intrathecal chemotherapy and rituximab administration. |
| Databáze: | OpenAIRE |
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