High Pregnane X Receptor (PXR) Expression Is Correlated with Poor Prognosis in Invasive Breast Carcinoma

Autor:	Lydia Nakopoulou, Panagiotis Sarantis, Nikolaos Tsoukalas, Stamatios Theocharis, Alexandros Pergaris, Constantinos Giaginis, Eugene Danas, Gerasimos Tsourouflis, Artemis Michail, Stefania Gourzi, Panagiotis K. Politis, Paraskevi Alexandrou
Rok vydání:	2021
Předmět:	Medicine (General) medicine.drug_class PXR Clinical Biochemistry clinicopathological parameters cell lines medicine.disease_cause digestive system Article R5-920 Breast cancer breast cancer patients’ prognosis Medicine Progesterone Receptor Negative Pregnane X receptor business.industry medicine.disease Phenotype digestive system diseases Estrogen immunohistochemistry Cancer research Immunohistochemistry business Breast carcinoma Carcinogenesis
Zdroj:	Diagnostics Volume 11 Issue 11 Diagnostics, Vol 11, Iss 1946, p 1946 (2021)
ISSN:	2075-4418
Popis:	Pregnane X Receptor (PXR) is involved in human cancer, either by directly affecting carcinogenesis or by inducing drug-drug interactions and chemotherapy resistance. The clinical significance of PXR expression in invasive breast carcinoma was evaluated in the present study. PXR protein expression was assessed immunohistochemically on formalin fixed paraffin-embedded breast invasive carcinoma tissue sections, obtained from 148 patients, and was correlated with clinicopathological parameters, molecular phenotypes, tumor cells’ proliferative capacity, and overall disease-free patients’ survival. Additionally, the expression of PXR was examined on human breast carcinoma cell lines of different histological grade, hormonal status, and metastatic potential. PXR positivity was noted in 79 (53.4%) and high PXR expression in 48 (32.4%), out of 148 breast carcinoma cases. High PXR expression was positively associated with nuclear grade (p = 0.0112) and histological grade of differentiation (p = 0.0305), as well as with tumor cells’ proliferative capacity (p = 0.0051), and negatively with luminal A subtype (p = 0.0295). Associations between high PXR expression, estrogen, and progesterone receptor negative status were also recorded (p = 0.0314 and p = 0.0208, respectively). High PXR expression was associated with shorter overall patients’ survival times (log-rank test, p = 0.0009). In multivariate analysis, high PXR expression was identified as an independent prognostic factor of overall patients’ survival (Cox-regression analysis, p = 0.0082). PXR expression alterations were also noted in breast cancer cell lines of different hormonal status. The present data supported evidence that PXR was related to a more aggressive invasive breast carcinoma phenotype, being a strong and independent poor prognosticator.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cfb1502941b6f34207244bbda6afe86 https://pubmed.ncbi.nlm.nih.gov/34829293 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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