5-Methoxypsoralen photoadduct formation: conversion of monoadducts to crosslinks
| Autor: | L. A. Amici, Francis P. Gasparro |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Stereochemistry
Photochemistry Ultraviolet Rays medicine.medical_treatment Immunology Dermatology Molecular mechanics DNA Adducts Poly dA-dT Cellular dna medicine Immunology and Allergy Animals Psoriasis Radiology Nuclear Medicine and imaging Photosensitizer 5-methoxypsoralen Chromatography High Pressure Liquid Primary (chemistry) Oligonucleotide Chemistry General Medicine DNA Cross-Linking Reagents Photochemotherapy PUVA therapy Biophysics 5-Methoxypsoralen Methoxsalen Cattle |
| Zdroj: | Photodermatology, photoimmunologyphotomedicine. 11(4) |
| ISSN: | 0905-4383 |
| Popis: | 5-Methoxypsoralen is often substituted for 8-methoxypsoralen in the photochemotherapy of psoriasis even though the nature of the resulting photadducts in cellular DNA has not been determined. A recent molecular mechanics study with a model oligonucleotide predicted that intercalated 5-methoxypsoralen molecules would tend to favor the preferential formation of 3,4-monoadducts. Such a result would be contrary to the photoadduct patterns observed with other psoralens. In this study we show that 5-methoxypsoralen photoadducts formation is, in fact, very similar to that for other psoralens, i.e., the primary photoadduct is the 4',5'-monoadduct which can be quantitatively converted to crosslink. |
| Databáze: | OpenAIRE |
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