Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene
| Autor: | Wan, Emily S, Castaldi, Peter J, Cho, Michael H, Hokanson, John E, Regan, Elizabeth A, Make, Barry J, Beaty, Terri H, Han, MeiLan K, Curtis, Jeffrey L, Curran-Everett, Douglas, Lynch, David A, DeMeo, Dawn L, Crapo, James D, Silverman, Edwin K, COPDGene Investigators |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Multivariate analysis Cross-sectional study Respiratory System Genome-wide association study Cardiorespiratory Medicine and Haematology Cohort Studies Pulmonary Disease Chronic Obstructive 0302 clinical medicine Epidemiology 80 and over Restriction Cluster Analysis 2.1 Biological and endogenous factors 030212 general & internal medicine Aetiology Lung Aged 80 and over COPD medicine.diagnostic_test Smoking Middle Aged 3. Good health Respiratory Female Cohort study Spirometry Pulmonary and Respiratory Medicine medicine.medical_specialty Chronic Obstructive Chronic Obstructive Pulmonary Disease Clinical Sciences Pulmonary Disease 03 medical and health sciences FEV1/FVC ratio Clinical Research Internal medicine Tobacco medicine Genetics Humans Lung diseases Aged COPDGene Investigators Tobacco Smoke and Health business.industry Research Human Genome medicine.disease eye diseases Good Health and Well Being Cross-Sectional Studies 030228 respiratory system Physical therapy business Genome-Wide Association Study |
| Zdroj: | Respiratory research, vol 15, iss 1 Wan, E S, Castaldi, P J, Cho, M H, Hokanson, J E, Regan, E A, Make, B J, Beaty, T H, Han, M K, Curtis, J L, Curran-Everett, D, Lynch, D A, DeMeo, D L, Crapo, J D, Silverman, E K, COPDGene Investigators & Mattheisen, M 2014, ' Epidemiology, genetics, and subtyping of preserved ratio impaired spirometry (PRISm) in COPDGene ' Respiratory Research Review, vol. 15, pp. 89 . https://doi.org/10.1186/s12931-014-0089-y Respiratory Research |
| Popis: | Background Preserved Ratio Impaired Spirometry (PRISm), defined as a reduced FEV1 in the setting of a preserved FEV1/FVC ratio, is highly prevalent and is associated with increased respiratory symptoms, systemic inflammation, and mortality. Studies investigating quantitative chest tomographic features, genetic associations, and subtypes in PRISm subjects have not been reported. Methods Data from current and former smokers enrolled in COPDGene (n = 10,192), an observational, cross-sectional study which recruited subjects aged 45–80 with ≥10 pack years of smoking, were analyzed. To identify epidemiological and radiographic predictors of PRISm, we performed univariate and multivariate analyses comparing PRISm subjects both to control subjects with normal spirometry and to subjects with COPD. To investigate common genetic predictors of PRISm, we performed a genome-wide association study (GWAS). To explore potential subgroups within PRISm, we performed unsupervised k-means clustering. Results The prevalence of PRISm in COPDGene is 12.3%. Increased dyspnea, reduced 6-minute walk distance, increased percent emphysema and decreased total lung capacity, as well as increased segmental bronchial wall area percentage were significant predictors (p-value |
| Databáze: | OpenAIRE |
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