Suppressing Effect of Tannic Acid on UV and Chemically Induced Chromosome Aberrations in Cultured Mammalian Cells
| Autor: | Yasuhiko Shirasu, Toshihiro Ohta, Mie Watanabe, Kyomu Matsumoto, Hisako Imanishi, YūF. Sasaki |
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| Rok vydání: | 1988 |
| Předmět: |
Chinese hamster ovary cell
Hamster Mutagen macromolecular substances medicine.disease_cause General Biochemistry Genetics and Molecular Biology chemistry.chemical_compound chemistry Biochemistry Cell culture Tannic acid medicine Gallic acid General Agricultural and Biological Sciences Antimutagen Mitosis |
| Zdroj: | Agricultural and Biological Chemistry. 52:2423-2428 |
| ISSN: | 0002-1369 |
| DOI: | 10.1080/00021369.1988.10869061 |
| Popis: | UV-induced structural chromosome aberrations were suppressed by post-treatment with tannic acid (w-galoyl gallic acid) in cultured Chinese hamster ovary cells. A significant decrease in the frequencies of chromosome aberrations in the presence of tannic acid was observed in cells treated with mitomycin C or methylmethanesulfonate but not with X-rays or bleomycin. The effects of tannic acid were dependent on the DNA pre-replicational Gl phase of the cell cycle. Furthermore, tannic acid enhanced the liquid-holding effect on UV-irradiated cells at Gl phase. On the other hand, the number of surviving UV-irradiated cells increased in the presence of tannic acid. These results suggest the possibility of promotion by tannic acid of an excision repair system of mammalian cells. |
| Databáze: | OpenAIRE |
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