Synthesis and crystal structure of 1,4,10,13-tetraoxa-7,16-diazoniumcyclo-octadecane bis(4-chloro-2-methyl-phenoxyacetate)
| Autor: | R. G. Mirskov, Mirskova Anna N, Sergey N. Adamovich, Uwe Schilde |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
chemistry.chemical_classification
Chemistry(all) Hydrogen bond Intermolecular force Infrared spectroscopy General Chemistry Crystal structure Preliminary Communication Dihedral angle Medicinal chemistry chemistry.chemical_compound Crystallography Chemistry chemistry Octadecane ddc:540 Institut für Chemie Carboxylate QD1-999 Crown ether |
| Zdroj: | Chemistry Central Journal, Vol 5, Iss 1, p 23 (2011) Chemistry Central Journal |
| Popis: | The title compound was prepared by the reaction of 1,4,10,13-tetraoxa-7,16-diazacyclo-octadecane with 4-chloro-2-methyl-phenoxyacetic acid in a ratio of 1:2. The structure has been proved by the data of elemental analysis, IR spectroscopy, NMR (1H, 13C) technique and by X-ray diffraction analysis. Intermolecular hydrogen bonds between the azonium protons and oxygen atoms of the carboxylate groups were found. Immunoactive properties of the title compound have been screened. The compound has the ability to suppress spontaneous and Con A-stimulated cell proliferation in vitro and therefore can be considered as immunodepressant. |
| Databáze: | OpenAIRE |
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