Increased psychological and attenuated cortisol and alpha-amylase responses to acute psychosocial stress in female patients with borderline personality disorder

Autor: Jana Mauchnik, Ulrike Ehlert, Ulrich W. Ebner-Priemer, Urs M. Nater, Beate Ditzen, Martin Bohus, Nikolaus Kleindienst, Jens Gaab, Elvira Abbruzzese
Přispěvatelé: University of Zurich, Nater, U M
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Bipolar I disorder
Hydrocortisone
Endocrinology
Diabetes and Metabolism
Pituitary-Adrenal System
Social Environment
Norepinephrine
2738 Psychiatry and Mental Health
Endocrinology
Cognition
Borderline Personality Disorder
Borderline personality disorder
media_common
10093 Institute of Psychology
1310 Endocrinology
Diagnostic and Statistical Manual of Mental Disorders
Psychiatry and Mental health
2712 Endocrinology
Diabetes and Metabolism
2807 Endocrine and Autonomic Systems
Schizophrenia
Female
Psychology
Psychosocial
2803 Biological Psychiatry
medicine.drug
Adult
Personality Tests
endocrine system
medicine.medical_specialty
Hypothalamo-Hypophyseal System
Epinephrine
media_common.quotation_subject
Adrenocorticotropic hormone
behavioral disciplines and activities
Adrenocorticotropic Hormone
Internal medicine
mental disorders
medicine
Humans
Saliva
Biological Psychiatry
Menstrual cycle
Endocrine and Autonomic Systems
Stressor
medicine.disease
Case-Control Studies
alpha-Amylases
150 Psychology
Stress
Psychological
DOI: 10.5167/uzh-35981
Popis: Summary Objective Borderline personality disorder (BPD) is characterized by increased self-reported stress and emotional responding. Knowledge about the psychological and physiological mechanisms that underlie these experiences in BPD patients is scarce. The objective was to assess both psychological and endocrinological responses to a standardized psychosocial stressor in female BPD patients and healthy controls. Methods A total of 15 female BPD patients and 17 healthy control subjects were included in a case–control study. All subjects were free of any medication, had a regular menstrual cycle, and were investigated during the luteal phase of their menstrual cycle. Co-occurring current major depression, current substance abuse/dependence, and lifetime schizophrenia or bipolar I disorder were excluded. Psychological measures of stress, salivary cortisol, salivary alpha-amylase, plasma ACTH, plasma norepinephrine and epinephrine concentrations were measured before, during, and after exposure to a standardized psychosocial stress protocol. Results BPD patients displayed maladaptive cognitive appraisal processes regarding the upcoming stressor as well as significantly higher subjective stress, coupled with a substantial cortisol and alpha-amylase hyporeactivity to the stressor in comparison to the controls. No significant differences for ACTH and catecholaminergic responses were observed, while the ACTH:cortisol ratio was higher in BPD patients than in controls. Conclusions Attenuated cortisol responsiveness in BPD patients might in part be explained by decreased adrenal responsiveness to endogenous ACTH and altered central noradrenergic activation as reflected by alpha-amylase.
Databáze: OpenAIRE
Externí odkaz: