Natural polyphenols improve erectile function and lipid profile in patients suffering from erectile dysfunction
| Autor: | Bujdak P, Jana Muchová, B Trebaticky, Jan Breza, Zdenka Durackova, Stanislav Ziaran |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Economics and Econometrics medicine.medical_specialty Sexual Behavior 030232 urology & nephrology Placebo Diabetes Complications 03 medical and health sciences 0302 clinical medicine Double-Blind Method Erectile Dysfunction Surveys and Questionnaires Internal medicine Diabetes mellitus Materials Chemistry Media Technology medicine Humans In patient medicine.diagnostic_test business.industry Penile Erection Polyphenols Forestry Middle Aged Erectile function medicine.disease Lipids Early complication Treatment Outcome 030104 developmental biology Erectile dysfunction Diabetes Mellitus Type 2 Polyphenol Lipid profile business |
| Zdroj: | Bratislava Medical Journal. 120:941-944 |
| ISSN: | 1336-0345 |
| DOI: | 10.4149/bll_2019_158 |
| Popis: | Objectives Erectile dysfunction (ED) is characterised as the inability to achieve or maintain an erection to complete sexual intercourse. ED may be considered as an early complication of diabetes mellitus (DM). The aim of this study was to assess the effect of registered food supplement, natural polyphenolic extract from the French maritime pine bark, Pycnogenol (PYC) on erectile function and lipid profile in ED patients. Methods 53 patients with ED were divided into two groups (32 with DM, 21 non-DM) in randomised, blinded and placebo-controlled study. During 3-month intervention with PYC or placebo and one month after the end of the intervention patients were investigated for ED with validated questionnaire International Index of Erectile Function-5 (IIEF-5); lipid profile, glycaemia was analysed in each group. Results In a randomised, blinded and placebo-controlled study, we found that natural polyphenolic extract, Pycnogenol improved erectile function in DM group by 45 % compared to the NDM group, where the improvement was also significant, but only by 22 %. Total cholesterol, LDL-cholesterol and glucose level was lowered by PYC in patients with DM. Glucose level was not affected by PYC in non-DM. Placebo showed no effect on monitored parameters in both groups. Conclusion Administration of Pycnogenol leads in improvement of erectile function in patients with ED and diabetes (DM group) by 45 %, in NDM group by 22 %, in lowering of total-, LDL-cholesterol by 20 % and 21 % and glycaemia by 22 % in DM (Tab. 2, Fig. 2, Ref. 19). |
| Databáze: | OpenAIRE |
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