Preparation of resveratrol dry suspension and its immunomodulatory and anti-inflammatory activity in mice
| Autor: | Renyong Jia, Min Cui, Meng Chen, Abaidullah Muhammad, Qiuting Fu, Yuanfeng Zou, Zhongqiong Yin, Gang Ye, Lixia Li, Changliang He, Lizi Yin, Xu Song, Xiaoxia Liang, Cheng Lv, Juan Huang |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
quality assessment medicine.drug_class Immunologic Factors Indomethacin Anti-Inflammatory Agents Pharmaceutical Science Context (language use) Inflammation Orthogonal design RM1-950 Pharmacology Resveratrol 030226 pharmacology & pharmacy 01 natural sciences Anti-inflammatory 03 medical and health sciences chemistry.chemical_compound Mice 0302 clinical medicine Suspensions Drug Discovery medicine Animals granuloma Cyclophosphamide Dose-Response Relationship Drug Chemistry Quality assessment food and beverages General Medicine 0104 chemical sciences 010404 medicinal & biomolecular chemistry Disease Models Animal Complementary and alternative medicine Polyphenol splenic lymphocytes Molecular Medicine Cytokines Female Therapeutics. Pharmacology medicine.symptom Immunosuppressive Agents Research Article |
| Zdroj: | Pharmaceutical Biology Pharmaceutical Biology, Vol 58, Iss 1, Pp 8-15 (2020) |
| ISSN: | 1744-5116 1388-0209 |
| Popis: | Context: Resveratrol is a natural polyphenol compound. It exhibits antitumor, immunostimulatory, and antiviral activities. However, poor water solubility and structural instability limit its administration and storage. Objective: A resveratrol dry suspension (RDS) was prepared and immunomodulatory effect in immunosuppressive mice induced by cyclophosphamide and anti-inflammatory activities in mice were evaluated. Materials and methods: The preparation of RDS was optimized by the orthogonal design method. To evaluate the immunomodulatory effects, SPF Kunming mice were divided into seven groups comprising of nine males and nine females for each group. The RDS supplemented group was administrated doses of 3.33, 1.67, and 0.83 g/kg/d. Then visceral index, lymphocyte proliferation, the ratio of CD3+ CD4+/CD3+ CD8+, and the contents of cytokines in serum were tested. To ameliorate effects of acetic acid induced capillary permeability, xylene-based ear oedema, and cotton pellet granuloma, RDS as anti-inflammatory agent was administered at doses of 1, 0.33, and 0.1 g/kg/d as compared to indomethacin (IM) provided as a positive control at 10 mg/kg. Results: RDS inhibited the degradation of resveratrol and enhanced the CD3+ CD4+/CD3+ CD8+ ratio, spleen index, IL-2 level, and splenic lymphocytes in immunosuppressive mice. RDS (0.1 g/kg/d) significantly inhibited the acetic acid-induced capillary permeability, and at doses of 0.33 and 1 g/kg/d repressed the ear swelling and granuloma formation in immunocompromised mice. Discussion and Conclusion: RDS is a stable, cheaper, and suitable preparation with potent immunoregulatory and anti-inflammatory activities. Keeping in view these remarkable properties, RDS could be an appropriate preparation for clinic use of resveratrol. |
| Databáze: | OpenAIRE |
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