MDM2 SNP309 accelerates familial breast carcinogenesis independently of estrogen signaling
| Autor: | Ans M.W. van den Ouweland, Cecile T. M. Brekelmans, Mieke Schutte, Jan G. M. Klijn, Jord H. A. Nagel, Hanne Meijers-Heijboer, Marijke Wasielewski |
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| Přispěvatelé: | Human Genetics, Medical Oncology, Clinical Genetics |
| Jazyk: | angličtina |
| Rok vydání: | 2007 |
| Předmět: |
Adult
Cancer Research Tumor suppressor gene medicine.drug_class Genes BRCA2 Genes BRCA1 Single-nucleotide polymorphism Breast Neoplasms Biology medicine.disease_cause Polymorphism Single Nucleotide Breast cancer Risk Factors Genotype medicine Humans Genetic Predisposition to Disease Breast skin and connective tissue diseases CHEK2 Germ-Line Mutation Cancer Estrogens Proto-Oncogene Proteins c-mdm2 Middle Aged medicine.disease Cell Transformation Neoplastic Oncology Estrogen Case-Control Studies Cancer research Female Carcinogenesis Signal Transduction |
| Zdroj: | Breast cancer research and treatment, 104(2), 153-157. Springer New York Breast Cancer Research and Treatment, 104(2), 153-157. Springer New York |
| ISSN: | 0167-6806 |
| DOI: | 10.1007/s10549-006-9407-5 |
| Popis: | A single nucleotide polymorphism (SNP309T>G) in the intronic promoter of MDM2 was recently found to accelerate carcinogenesis in early-onset cancer cases. This cancer acceleration presumably was due to increased SP1 binding, resulting in enhanced MDM2 transcriptional activation by estrogens. We evaluated MDM2 SNP309 in 343 familial breast cancer cases with known mutation status for CHEK2 1100delC, BRCA1 and BRCA2. Cancer acceleration was indeed observed in early-onset familial breast cancer cases (diagnosed |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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