Early Childhood Gut Microbiomes Show Strong Geographic Differences Among Subjects at High Risk for Type 1 Diabetes
| Autor: | Kaisa M, Kemppainen, Alexandria N, Ardissone, Austin G, Davis-Richardson, Jennie R, Fagen, Kelsey A, Gano, Luis G, León-Novelo, Kendra, Vehik, George, Casella, Olli, Simell, Anette G, Ziegler, Marian J, Rewers, Åke, Lernmark, William, Hagopian, Jin-Xiong, She, Jeffrey P, Krischer, Beena, Akolkar, Desmond A, Schatz, Mark A, Atkinson, Eric W, Triplett, Dan, Gallo |
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| Rok vydání: | 2014 |
| Předmět: |
Male
Research design Endocrinology Diabetes and Metabolism Population The Environmental Determinants of Diabetes in the Young Pilot Projects Gram-Positive Bacteria Feces Residence Characteristics Risk Factors Germany RNA Ribosomal 16S Gram-Negative Bacteria Genotype Internal Medicine medicine Humans Microbiome Early childhood education Finland Sweden 2. Zero hunger Advanced and Specialized Nursing Type 1 diabetes education.field_of_study business.industry Microbiota Infant medicine.disease United States 3. Good health Intestines Novel Communications in Diabetes Diabetes Mellitus Type 1 Child Preschool Female business Dysbiosis Demography |
| Zdroj: | Diabetes Care 38, 329-332 (2015) Diabetes Care |
| ISSN: | 1935-5548 0149-5992 |
| DOI: | 10.2337/dc14-0850 |
| Popis: | OBJECTIVE Gut microbiome dysbiosis is associated with numerous diseases, including type 1 diabetes. This pilot study determines how geographical location affects the microbiome of infants at high risk for type 1 diabetes in a population of homogenous HLA class II genotypes. RESEARCH DESIGN AND METHODS High-throughput 16S rRNA sequencing was performed on stool samples collected from 90 high-risk, nonautoimmune infants participating in The Environmental Determinants of Diabetes in the Young (TEDDY) study in the U.S., Germany, Sweden, and Finland. RESULTS Study site–specific patterns of gut colonization share characteristics across continents. Finland and Colorado have a significantly lower bacterial diversity, while Sweden and Washington state are dominated by Bifidobacterium in early life. Bacterial community diversity over time is significantly different by geographical location. CONCLUSIONS The microbiome of high-risk infants is associated with geographical location. Future studies aiming to identify the microbiome disease phenotype need to carefully consider the geographical origin of subjects. |
| Databáze: | OpenAIRE |
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