Inhibition of reactive nitrogen species production in COPD airways: comparison of inhaled corticosteroid and oral theophylline
| Autor: | Kazuhito Ueshima, Kazuto Matsunaga, Keiichirou Akamatsu, Masanori Nakanishi, Yuko Yamagata, Satoru Yanagisawa, Yoshiaki Minakata, Mikako Gohda, Toshiyuki Yamagata, Tomohiro Ichikawa, Masakazu Ichinose, Tsunahiko Hirano |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine medicine.drug_class Chronic Obstructive Pulmonary Disease Vital Capacity Administration Oral Pharmacology Fluticasone propionate Pulmonary Disease Chronic Obstructive Theophylline Adrenal Cortex Hormones Forced Expiratory Volume Administration Inhalation medicine Humans Aged Fluticasone COPD Cross-Over Studies Inhalation business.industry medicine.disease Reactive Nitrogen Species Crossover study Bronchodilator Agents respiratory tract diseases Androstadienes Oxidative Stress Editorial Anesthesia Sputum Corticosteroid Female medicine.symptom business medicine.drug |
| Zdroj: | Thorax. 61:761-766 |
| ISSN: | 0040-6376 |
| DOI: | 10.1136/thx.2005.058156 |
| Popis: | Reactive nitrogen species (RNS) are thought to be one of the important factors in the pathogenesis of chronic obstructive pulmonary disease (COPD). A study was undertaken to examine the effects of theophylline and fluticasone propionate (FP) on RNS production in subjects with COPD.Sixteen COPD subjects participated in the study. Theophylline (400 mg/day orally) or FP (400 mug/day inhalation) were administered for 4 weeks in a randomised crossover manner with a washout period of 4 weeks. Induced sputum was collected at the beginning and end of each treatment period. 3-nitrotyrosine (3-NT), which is a footprint of RNS, was quantified by high performance liquid chromatography with an electrochemical detection method as well as by immunohistochemical staining.Theophylline significantly reduced the level of 3-NT in the sputum supernatant as well as the number of 3-NT positive cells (both p0.01). FP also reduced 3-NT formation, but the effect was smaller than that of theophylline. Theophylline also significantly reduced the neutrophil cell counts in the sputum (p0.01), while FP treatment had no effect on the number of inflammatory cells in the sputum, except eosinophils.Theophylline reduces nitrative stress and neutrophil infiltration in COPD airways to a larger extent than inhaled corticosteroid. |
| Databáze: | OpenAIRE |
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