Altered Sarcoplasmic Reticulum Ca2+ATPase Gene Expression in Congestive Heart Failure: Effect of Chronic Norepinephrine Infusion
| Autor: | Joseph M. Delehanty, Chang-seng Liang, Ling Ping Lai, Akito Yatani, Vulapalli S Raju |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Hemodynamics Calcium-Transporting ATPases Calsequestrin Gene Expression Regulation Enzymologic Norepinephrine (medication) Norepinephrine Dogs Microsomes Calcium-binding protein Internal medicine medicine Animals Infusions Parenteral RNA Messenger Molecular Biology Heart Failure Chemistry Ryanodine receptor Myocardium Endoplasmic reticulum Calcium-Binding Proteins Cardiac Pacing Artificial Ryanodine Receptor Calcium Release Channel medicine.disease Phospholamban Sarcoplasmic Reticulum Endocrinology Heart failure Cardiology and Cardiovascular Medicine medicine.drug |
| Zdroj: | Journal of Molecular and Cellular Cardiology. 30:175-185 |
| ISSN: | 0022-2828 |
| DOI: | 10.1006/jmcc.1997.0583 |
| Popis: | We have examined the ryanodine receptor, Ca(2+)-ATPase, calsequestrin and phospholamban mRNA levels in the left ventricles of pacing-induced heart failure and norepinephrine infusion dogs. The heart failure dogs showed a decrease in the levels of ryanodine receptor and Ca(2+)-ATPase mRNAs. Norepinephrine infusion caused a reduction of Ca(2+)-ATPase mRNA but no change in ryanodine receptor mRNA. There was a corresponding reduction of the immunoreactive Ca(2+)-ATPase protein levels in both heart failure and norepinephrine infusion animals compared to controls. In contrast, the mRNAs of calsequestrin and phospholamban were unchanged in dogs with either congestive heart failure or norepinephrine infusion. Thus, since norepinephrine infusion and congestive heart failure produced similar reductions of Ca(2+)-ATPase mRNA and protein, we postulate that the down-regulation of Ca(2+)-ATPase in congestive heart failure may be caused, at least in part, by sympathetic stimulation that occurs in heart failure. |
| Databáze: | OpenAIRE |
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