Association of body mass index in early adulthood and middle age with future site-specific cancer mortality: the Harvard Alumni Health Study
Autor: | Howard D. Sesso, G. D. Batty, Linsay Gray, I-Min Lee |
---|---|
Rok vydání: | 2012 |
Předmět: |
Adult
Male Gerontology medicine.medical_specialty Adolescent Epidemiology body mass index Cohort Studies Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Neoplasms cohort study medicine Humans 030212 general & internal medicine Risk factor Young adult Adiposity 2. Zero hunger Harvard alumni health study Cancer Death Rate Obstetrics business.industry Hazard ratio Original Articles Hematology Middle Aged mortality Confidence interval Middle age 3. Good health Oncology 030220 oncology & carcinogenesis Harvard business Body mass index |
Zdroj: | Annals of Oncology |
ISSN: | 0923-7534 |
DOI: | 10.1093/annonc/mdr270 |
Popis: | Background: The association between adiposity in early adulthood and subsequent development of specific malignancies is unclear. Further, the potential for mediation by adiposity in middle age has not been well examined. In a rare study, we investigated the association of body mass index (BMI) in early adulthood with mortality from several site-specific cancers. Design: In the Harvard Alumni Health Study cohort, 19 593 males had a physical examination at the university between 1914 and 1952 (mean age: 18.4 years) and returned a questionnaire in 1962 or 1966 (mean age = 45.1 years). BMI was computed using weight (kg)/height2 (m2) at both time points. Vital status follow up continued for a maximum of 82 years. Results: Positive early adulthood cancer mortality gradients by BMI were found for all malignancies combined (adjusted hazard ratio [HR] = 1.11; 95% confidence interval [CI]: 1.05–1.17 for a one standard deviation increase in early adulthood BMI), and for lung (HR = 1.24; 95% CI = 1.10–1.40) and skin (HR = 1.29; 95% CI = 0.96–1.75) cancers. There were also apparent associations for cancers of the oesophagus and urogenital sites. Mediation by BMI in middle age was found to be minimal. Conclusion: Higher BMI in early adulthood appears to be a direct risk factor for selected malignancies several decades later. |
Databáze: | OpenAIRE |
Externí odkaz: |