Fluorescent water soluble polymers for isozyme-selective interactions with matrix metalloproteinase-9
| Autor: | Daniel L. Friesner, Manas K. Haldar, Sanku Mallik, Rinku Dutta, Bratati Ganguly, D. K. Srivastava, Michael D. Scott |
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| Rok vydání: | 2011 |
| Předmět: |
chemistry.chemical_classification
Polymers Organic Chemistry Clinical Biochemistry Fluorescence spectrometry Pharmaceutical Science Biological activity Polymer Matrix metalloproteinase Biochemistry Fluorescence Isozyme Article Amino acid Spectrometry Fluorescence Enzyme Matrix Metalloproteinase 9 Solubility chemistry Drug Discovery Molecular Medicine Molecular Biology Fluorescent Dyes |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 21:2007-2010 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/j.bmcl.2011.02.020 |
| Popis: | Matrix metalloproteinases (MMPs) are overexpressed in various pathological conditions, including various cancers. Although these isozymes have similar active sites, the patterns of exposed amino acids on their surfaces are different. Herein, we report the synthesis and molecular interactions of two water-soluble, fluorescent polymers which demonstrate selective interactions with MMP-9 compared to MMP-7 and -10. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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