Exercise training for people following curative intent treatment for non-small cell lung cancer: a randomized controlled trial
Autor: | Martin J. Phillips, Kevin Gain, Vinicius Cavalheri, Nola Cecins, Lucas H.A. Sanders, Sue Jenkins, Kylie Hill |
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Rok vydání: | 2017 |
Předmět: |
medicine.medical_specialty
Lung Neoplasms medicine.medical_treatment education Population Physical Therapy Sports Therapy and Rehabilitation Non-small cell Quadriceps Muscle law.invention Exercise training 03 medical and health sciences Oxygen Consumption 0302 clinical medicine Randomized controlled trial Quality of life law Carcinoma Non-Small-Cell Lung medicine Humans Orthopedics and Sports Medicine Pulmonary rehabilitation Muscle Strength Lung cancer Original Research education.field_of_study Rehabilitation Hand Strength business.industry Carcinoma respiratory system medicine.disease Confidence interval respiratory tract diseases Exercise Therapy 030228 respiratory system Case-Control Studies 030220 oncology & carcinogenesis Exercise Test Quality of Life Physical therapy Anxiety medicine.symptom business |
Zdroj: | Brazilian Journal of Physical Therapy |
ISSN: | 1413-3555 |
Popis: | Highlights • Lung resection for lung cancer is associated with marked reductions in exercise capacity. • Exercise training increased exercise capacity in people with non-small cell lung cancer. • Exercise training did not improve other outcomes. Objective In people following curative intent treatment for non-small cell lung cancer, to investigate the effects of supervised exercise training on exercise capacity, physical activity and sedentary behavior, peripheral muscle force, health-related quality of life, fatigue, feelings of anxiety and depression, and lung function. Method This pilot randomized controlled trial included participants 6–10 weeks after lobectomy for non-small cell lung cancer or, for those who required adjuvant chemotherapy, 4–8 weeks after their last cycle. Participants were randomized to either 8 weeks of supervised exercise training (exercise group) or 8 weeks of usual care (control group). Prior to and following the intervention period, both groups completed measurements of exercise capacity, physical activity and sedentary behavior, quadriceps and handgrip force, HRQoL, fatigue, feelings of anxiety and depression, and lung function. Intention-to-treat analysis was undertaken. Results Seventeen participants (mean age 67, SD = 9 years; 12 females) were included. Nine and eight participants were randomized to the exercise and control groups, respectively. Four participants (44%) adhered to exercise training. Compared with any change seen in the control group, those in the exercise group demonstrated greater gains in the peak rate of oxygen consumption (mean difference, 95% confidence interval for between-group difference: 0.19 [0.04–0.33] L min−1) and 6-minute walk distance (52 [12–93] m). No other between-group differences were demonstrated. Conclusions In people following curative intent treatment for non-small cell lung cancer, 8 weeks of supervised exercise training improved exercise capacity, measured by both laboratory- and field-based exercise tests. These results suggest that this clinical population may benefit from attending exercise training programs. |
Databáze: | OpenAIRE |
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