Exercise training for people following curative intent treatment for non-small cell lung cancer: a randomized controlled trial

Autor: Martin J. Phillips, Kevin Gain, Vinicius Cavalheri, Nola Cecins, Lucas H.A. Sanders, Sue Jenkins, Kylie Hill
Rok vydání: 2017
Předmět:
medicine.medical_specialty
Lung Neoplasms
medicine.medical_treatment
education
Population
Physical Therapy
Sports Therapy and Rehabilitation
Non-small cell
Quadriceps Muscle
law.invention
Exercise training
03 medical and health sciences
Oxygen Consumption
0302 clinical medicine
Randomized controlled trial
Quality of life
law
Carcinoma
Non-Small-Cell Lung
medicine
Humans
Orthopedics and Sports Medicine
Pulmonary rehabilitation
Muscle Strength
Lung cancer
Original Research
education.field_of_study
Rehabilitation
Hand Strength
business.industry
Carcinoma
respiratory system
medicine.disease
Confidence interval
respiratory tract diseases
Exercise Therapy
030228 respiratory system
Case-Control Studies
030220 oncology & carcinogenesis
Exercise Test
Quality of Life
Physical therapy
Anxiety
medicine.symptom
business
Zdroj: Brazilian Journal of Physical Therapy
ISSN: 1413-3555
Popis: Highlights • Lung resection for lung cancer is associated with marked reductions in exercise capacity. • Exercise training increased exercise capacity in people with non-small cell lung cancer. • Exercise training did not improve other outcomes.
Objective In people following curative intent treatment for non-small cell lung cancer, to investigate the effects of supervised exercise training on exercise capacity, physical activity and sedentary behavior, peripheral muscle force, health-related quality of life, fatigue, feelings of anxiety and depression, and lung function. Method This pilot randomized controlled trial included participants 6–10 weeks after lobectomy for non-small cell lung cancer or, for those who required adjuvant chemotherapy, 4–8 weeks after their last cycle. Participants were randomized to either 8 weeks of supervised exercise training (exercise group) or 8 weeks of usual care (control group). Prior to and following the intervention period, both groups completed measurements of exercise capacity, physical activity and sedentary behavior, quadriceps and handgrip force, HRQoL, fatigue, feelings of anxiety and depression, and lung function. Intention-to-treat analysis was undertaken. Results Seventeen participants (mean age 67, SD = 9 years; 12 females) were included. Nine and eight participants were randomized to the exercise and control groups, respectively. Four participants (44%) adhered to exercise training. Compared with any change seen in the control group, those in the exercise group demonstrated greater gains in the peak rate of oxygen consumption (mean difference, 95% confidence interval for between-group difference: 0.19 [0.04–0.33] L min−1) and 6-minute walk distance (52 [12–93] m). No other between-group differences were demonstrated. Conclusions In people following curative intent treatment for non-small cell lung cancer, 8 weeks of supervised exercise training improved exercise capacity, measured by both laboratory- and field-based exercise tests. These results suggest that this clinical population may benefit from attending exercise training programs.
Databáze: OpenAIRE
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