Toll like receptors: a new hope on the horizon to treat multiple sclerosis

Autor:	Ali Reza Aleyasin, Amir Hossein Abdolghaffari, Nima Rezaei, Maziar Gooshe
Rok vydání:	2014
Předmět:	Multiple Sclerosis Innate immune system biology business.industry Multiple sclerosis Toll-Like Receptors Immunology Pattern recognition receptor medicine.disease Immunomodulation Toll biology.protein Humans Immunology and Allergy Medicine business Receptor Neuroscience
Zdroj:	Expert Review of Clinical Immunology. 10:1277-1279
ISSN:	1744-8409 1744-666X
Popis:	Evolving data have shown that the toll like receptors (TLRs) family of innate immune receptors has an important role in driving the activation and inhibition of pathogenic pathways involved in multiple sclerosis (MS). While developing clinical trials targeting MS by TLRs modulators are of considerable interest, several of them have failed. Herein, the various consequences of TLRs pathways activation and the potential of targeting these receptors for therapeutic purposes are described. In particular, different aspects of TLR based therapies are discussed, in order to develop more efficacious and safe therapies targeting inflammatory and autoimmune diseases, especially MS.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ce478d11025c05882e6f9462bb5ffb6 https://doi.org/10.1586/1744666x.2014.953061 Zobrazit plný text záznamu