The High Rate of de novo Graft Carcinomas in Renal Transplant Recipients
| Autor: | Vincent Elalouf, Maité Jaureguy, Nicolas Surga, Xavier Tillou, S. Collon, Ludovic Viart |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male medicine.medical_specialty Adolescent Population Urology Physical examination urologic and male genital diseases Nephrectomy Young Adult medicine Humans Child education Carcinoma Renal Cell Survival rate Kidney transplantation Aged Aged 80 and over Carcinoma Transitional Cell education.field_of_study medicine.diagnostic_test Ureteral Neoplasms business.industry Incidence Incidence (epidemiology) Cancer Middle Aged medicine.disease Kidney Transplantation Kidney Neoplasms Surgery Survival Rate Transitional cell carcinoma Nephrology Child Preschool Female Tomography X-Ray Computed business Organ Sparing Treatments Clear cell |
| Zdroj: | American Journal of Nephrology. 37:91-96 |
| ISSN: | 1421-9670 0250-8095 |
| Popis: | Background: To investigate the incidence, the clinical characteristics and outcomes of renal graft carcinomas in the same renal transplant population. Methods: From April 1989 to April 2012, 1,037 consecutive renal transplantations were performed in our department. Data were collected prospectively in an extensively maintained database. For all recipients, monitoring consisted of clinical examination and an abdominopelvic CT scan or ultrasonography at least once a year. Results: After 1,037 renal transplantations, 48 men and 14 women (sex ratio 3:4) with a mean age of 54 years (25.1–78.9) were included for urological malignancies. Eight graft carcinomas were identified: 7 renal cell carcinomas (5 papillary carcinomas and 2 clear cell carcinomas of the renal graft) and 1 transitional cell carcinoma of the ureteral graft (incidence 0.78%). Nephron-sparing surgery was chosen for 5 patients with good outcomes. All graft renal cell carcinomas were classified as pT1a and the mean size of tumors was 28.4 mm (range 6–45). The 5-year specific survival rate was 100%. No recurrence was observed with a mean follow-up of 36.8 months (4.1–84.3). Conclusion: Thus confirming an increased risk of de novo graft cancer, close monitoring of renal transplant recipients should be discussed with at least an abdominopelvic ultrasonography and PSA measurement once a year. Renal cell graft carcinomas seemed to be mostly small and of papillary type and low grade. |
| Databáze: | OpenAIRE |
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