Seasonality in the manifestation of type 1 diabetes varies according to age at diagnosis in Finnish children
| Autor: | Finnish Pediat Diabet Register, Turtinen, Maaret, Härkönen, Taina, Ilonen, Jorma, Parkkola, Anna, Knip, Mikael |
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| Přispěvatelé: | HUS Children and Adolescents, Children's Hospital, Clinicum, CAMM - Research Program for Clinical and Molecular Metabolism, Molecular and Integrative Biosciences Research Programme, Lastentautien yksikkö, Research Group Knip, Tampere University, Department of Paediatrics |
| Rok vydání: | 2022 |
| Předmět: |
RISK
Adolescent type 1 diabetes AUTOIMMUNITY Incidence CHILDHOOD General Medicine 3121 Internal medicine CLINICAL ONSET MELLITUS HLA class II Diabetes Mellitus Type 1 3123 Gynaecology and paediatrics Pediatrics Perinatology and Child Health Humans ISLET-CELL-ANTIBODIES IDDM GENDER Seasons Child clinical characteristics season Finland Autoantibodies |
| Zdroj: | Acta Paediatrica. 111:1061-1069 |
| ISSN: | 1651-2227 0803-5253 |
| DOI: | 10.1111/apa.16282 |
| Popis: | AIM: We tested the hypothesis of a more aggressive disease process at diagnosis of type 1 diabetes during fall and winter, the colder seasons with consistently observed higher incidence of type 1 diabetes. METHODS: Seasonality in the manifestation of type 1 diabetes was examined in 4993 Finnish children and adolescents. Metabolic characteristics, beta-cell autoantibodies and HLA class II genetics were analysed at clinical diagnosis. RESULTS: Significant seasonality was observed with higher number of new cases during fall and winter (n = 1353/27.1% and n = 1286/25.8%) compared with spring and summer (n = 1135/22.7% and n = 219/24.4%) (p |
| Databáze: | OpenAIRE |
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