Antidiarrhoeic activity of Euphorbia hirta extract and isolation of an active flavonoid constituent
| Autor: | M. D. Lorente, José Jiménez, M. A. Ocete, M. E. Crespo, Julio Gálvez, Antonio Zarzuelo |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.drug_class
Flavonoid Pharmaceutical Science Decoction Biology Crude drug Analytical Chemistry law.invention chemistry.chemical_compound Mice law Drug Discovery Antidiarrhoeal Intestine Small medicine Animals Rats Wistar Antidiarrheals Pharmacology chemistry.chemical_classification Euphorbia Plants Medicinal Traditional medicine Plant Extracts Organic Chemistry biology.organism_classification Quercitrin Rats Complementary and alternative medicine chemistry Castor oil Molecular Medicine Quercetin Phytotherapy medicine.drug |
| Zdroj: | Planta medica. 59(4) |
| ISSN: | 0032-0943 |
| Popis: | The antidiarrhoeic activity of the Euphorbia hirta whole plant was investigated. The lyophilized decoction demonstrated antidiarrhoeic activity in experimental models of diarrhoea induced by castor oil, arachidonic acid, and prostaglandin E2. It showed no activity when magnesium sulphate was used to provoke the diarrhoea. The lyophilized decoction delayed small intestinal transit when this was accelerated by castor oil but not in normal conditions. A flavonoid, quercitrin, with antidiarrhoeic activity was isolated from this crude drug. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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