The role of H1 antihistamines in contralateral breast cancer:a Danish nationwide cohort study
| Autor: | Timothy L. Lash, Niels Kroman, Deirdre Cronin-Fenton, Lene Mellemkjær, Søren Friis, Christian Dehlendorff, Maj-Britt Jensen, Bent Ejlertsen, Annet Bens |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Adult
Cancer Research medicine.medical_specialty medicine.medical_treatment Denmark Histamine H1 Antagonists/pharmacology Breast Neoplasms Article Danish Cohort Studies 03 medical and health sciences Young Adult 0302 clinical medicine Breast cancer Cancer epidemiology Breast Neoplasms/drug therapy Risk Factors Internal medicine parasitic diseases medicine Humans 030212 general & internal medicine Medical prescription Aged Chemotherapy business.industry Confounding Hazard ratio Middle Aged medicine.disease Confidence interval language.human_language Oncology 030220 oncology & carcinogenesis language Histamine H1 Antagonists Female business Cohort study |
| Zdroj: | Bens, A, Dehlendorff, C, Friis, S, Cronin-Fenton, D, Jensen, M-B, Ejlertsen, B, Lash, T L, Kroman, N & Mellemkjaer, L 2020, ' The role of H1 antihistamines in contralateral breast cancer : a Danish nationwide cohort study ', British Journal of Cancer, vol. 122, pp. 1102–1108 . https://doi.org/10.1038/s41416-020-0747-4 Bens, A, Dehlendorff, C, Friis, S, Cronin-Fenton, D, Jensen, M B, Ejlertsen, B, Lash, T L, Kroman, N & Mellemkjær, L 2020, ' The role of H1 antihistamines in contralateral breast cancer : a Danish nationwide cohort study ', British Journal of Cancer, vol. 122, no. 7, pp. 1102-1108 . https://doi.org/10.1038/s41416-020-0747-4 British Journal of Cancer Bens, A, Dehlendorff, C, Friis, S, Cronin-Fenton, D, Jensen, M-B, Ejlertsen, B, Lash, T L, Kroman, N & Mellemkjær, L 2020, ' The role of H1 antihistamines in contralateral breast cancer : a Danish nationwide cohort study ', British Journal of Cancer, vol. 122, no. 7, pp. 1102-1108 . https://doi.org/10.1038/s41416-020-0747-4 |
| Popis: | Background Preclinical studies have shown both pro- and antineoplastic effects of antihistamines. Here, we evaluated the effect of H1 antihistamines on contralateral breast cancer (CBC) risk, and whether cationic amphiphilic (CAD) antihistamines could increase the sensitivity to chemotherapy. Methods From the Danish Breast Cancer Group clinical database, we identified all women aged ≥20 years with a first-time diagnosis of breast cancer during 1996–2012. Information on drug use, CBC and potential confounding factors was retrieved from nationwide registries. Using Cox proportional hazard regression models, we calculated hazard ratios (HRs) and 95% confidence intervals (CIs) for CBC associated with H1-antihistamine use. Results We identified 52,723 patients with breast cancer with a total of 310,583 person-years of follow-up. Among them, 1444 patients developed a new primary tumour in the contralateral breast. Post-diagnosis use of H1 antihistamines (≥2 prescriptions) was not strongly associated with CBC risk (HR 1.08, 95% CI: 0.90–1.31) compared with non-use ( Conclusions Taken together, our findings do not suggest any association of H1-antihistamine use with CBC development. |
| Databáze: | OpenAIRE |
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