(E)-5-Benzyl-7-(3,4-dimethoxybenzylidene)-3-(3,4-dimethoxyphenyl)-2-phenyl-3,3a,4,5,6,7-hexahydro-2H-pyrazolo[4,3c] Pyridine
| Autor: | Hilwan Yuda Teruna, Elsa Natia Rindiana, Ihsan Ikhtiarudin, Adel Zamri, Noval Herfindo, Enda Mora, Neni Frimayanti |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
DPPH assay
monoketone curcumin analogue antioxidant intermolecular cyclization 010405 organic chemistry Chemistry DPPH pyrazolo-pyridine analogue Organic Chemistry Claisen schmidt condensation 010402 general chemistry 01 natural sciences Biochemistry Medicinal chemistry 0104 chemical sciences chemistry.chemical_compound Pyridine Physical and Theoretical Chemistry Claisen-Schmidt condensation Two-dimensional nuclear magnetic resonance spectroscopy Heteronuclear single quantum coherence spectroscopy Inorganic chemistry QD146-197 |
| Zdroj: | Molbank, Vol 2021, Iss M1240, p M1240 (2021) |
| ISSN: | 1422-8599 |
| Popis: | A new pyrazolo-pyridine analogue (title compound) was synthesized in two steps. The first stage was synthesis of monoketone curcumin analogue through Claisen–Schmidt reaction. The second stage was synthesis of the title compound through intermolecular cyclization under reflux condition. The structure of the title compound has been confirmed by spectroscopic analysis including UV, FT-IR, HRMS, 1D NMR (1H-NMR, 13C-NMR, 1D-TOCSY), and 2D NMR (COSY, HSQC, HMBC). Based on the DPPH assay, the compound has moderate antioxidant activity, with an IC50 value of 194.06 ± 7.88 µg/mL (0.337 mM). |
| Databáze: | OpenAIRE |
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