T cell abnormalities in mixed connective tissue disease complicated with Klinefelter's syndrome
| Autor: | Hirohisa Nakao, Yuji Matsuzawa, Yoshio Kanayama, Katsuhiko Ishihara, Masafumi Yoshimura, Yuzuru Kanakura |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Adult
Male T cell Lymphocyte CD8-Positive T-Lymphocytes Lymphocyte Activation Mixed connective tissue disease Klinefelter Syndrome Antigens CD T-Lymphocyte Subsets Internal Medicine medicine Humans Mixed Connective Tissue Disease Autoimmune disease Leukopenia business.industry General Medicine T lymphocyte HLA-DR Antigens medicine.disease Flow Cytometry medicine.anatomical_structure Sjogren's Syndrome Immunology Klinefelter syndrome medicine.symptom business CD8 |
| Zdroj: | Internal medicine (Tokyo, Japan). 33(11) |
| ISSN: | 0918-2918 |
| Popis: | We report a 28-year-old Japanese with Klinefelter's syndrome who developed mixed connective tissue disease (MCTD) and Sjogren syndrome. Previously being well, he presented with Raynaud's phenomenon, dry eye, fever and polyarthralgia. Clinical examinations revealed anti-nRNP autoantibodv, leukopenia and lung fibrosis. Then he was found to have Klinefelter's syndrome. Flow cytometric analysis showed a relative increase of peripheral CD8 + T lymphocytes carrying either HLA-DR or CD57. Lymphocyte IL-2 production induced in vitro by concanavalin A was decreased. Such T cell abnormalities may be implicated in the development of autoimmune disease in Klinefelter's syndrome |
| Databáze: | OpenAIRE |
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