Crocin promotes non-rapid eye movement sleep in mice
| Autor: | Masaki Mika, Yoshihiro Urade, Zhi-Li Huang, Kosuke Aritake, Yukihiro Shoyama, Hiroyuki Tanaka |
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| Rok vydání: | 2011 |
| Předmět: |
ved/biology.organism_classification_rank.species
Crocetin Administration Oral Sleep REM Pharmacology Non-rapid eye movement sleep Time Crocin chemistry.chemical_compound Mice mental disorders Crocus sativus Insomnia medicine Animals Vitamin A Carotenoid chemistry.chemical_classification Dose-Response Relationship Drug ved/biology business.industry Electroencephalography Crocus Sleep in non-human animals Carotenoids Dose–response relationship chemistry Anesthesia Sleep Stages medicine.symptom business Injections Intraperitoneal Food Science Biotechnology |
| Zdroj: | Molecular nutritionfood research. 56(2) |
| ISSN: | 1613-4133 |
| Popis: | Crocus sativus L. (saffron) has been traditionally used for the treatment of insomnia and other diseases of the nervous systems. Two carotenoid pigments, crocin and crocetin, are the major components responsible for the various pharmacological activities of C. sativus L. In this study, we examined the sleep-promoting activity of crocin and crocetin by monitoring the locomotor activity and electroencephalogram after administration of these components to mice. Crocin (30 and 100 mg/kg) increased the total time of non-rapid eye movement (non-REM) sleep by 60 and 170%, respectively, during a 4-h period from 20:00 to 24:00 after its intraperitoneal administration at a lights-off time of 20:00. Crocetin (100 mg/kg) also increased the total time of non-REM sleep by 50% after the administration. These compounds did not change the amount of REM sleep or show any adverse effects, such as rebound insomnia, after the induction of sleep. |
| Databáze: | OpenAIRE |
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