Effects of urban coarse particles inhalation on oxidative and inflammatory parameters in the mouse lung and colon

Autor: Laurent Y. Alleman, Adil Ouali Alami, Corinne Gower-Rousseau, Madjid Djouina, Pierre Desreumaux, Mathilde Body-Malapel, Esperanza Perdrix, Cécile Vignal, Muriel Pichavant, Florian Dingreville, Christophe Waxin
Přispěvatelé: Body-Malapel, Mathilde, Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 (CIIL), Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre National de la Recherche Scientifique (CNRS), Département Sciences de l'Atmosphère et Génie de l'Environnement, École des Mines de Douai (Mines Douai EMD), Institut Mines-Télécom [Paris] (IMT)-Institut Mines-Télécom [Paris] (IMT), Service de Gastroenterologie [CHRU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), This work was supported by the Hauts-de-France Region and the Ministère de l’Enseignement Supérieur et de la Recherche (CPER Climibio), the European Fund for Regional Economic Development, and Digestscience (European Research Foundation on Intestinal Diseases and Nutrition)., The authors thank Bruno Mallet., Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Université de Lille-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Pasteur de Lille, Inserm, Université de Lille, CHU Lille, Centre d'Infection et d'Immunité de Lille (CIIL) - U1019 - UMR 8204, Lille Inflammation Research International Center - U 995 [LIRIC], Centre d’Infection et d’Immunité de Lille - INSERM U 1019 - UMR 9017 - UMR 8204 [CIIL]
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Coarse PM
MESH: Air Pollutants
Health
Toxicology and Mutagenesis
medicine.medical_treatment
MESH: Solvents
010501 environmental sciences
Toxicology
medicine.disease_cause
01 natural sciences
[SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
Antioxidants
11. Sustainability
Gut-lung axis
N-acetyl-L-cysteine
MESH: Animals
[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology
Lung
Air Pollutants
Inhalation Exposure
MESH: Cytokines
MESH: Oxidative Stress
Inhalation
Mesh:Air Pollutants/toxicity
Mesh:Solubility
Mesh:Inflammation Mediators/immunology
Mesh:Mice
Mesh:Inbred C57BL
Mesh:Colon/immunology
Mesh:Colon/metabolism
Mesh:Acetylcysteine/pharmacology
Mesh:Animals
Mesh:Cytokines/metabolism
Mesh:Oxidative Stress/drug effects
Mesh:Colon/drug effects
Mesh:Water/chemistry
Mesh:Lung/drug effects
Mesh:Lung/metabolism
Mesh:Cytokines/immunology
Mesh:Air Pollutants/chemistry
Mesh:Antioxidants/pharmacology
Mesh:Male
Mesh:Inflammation Mediators/metabolism
Mesh:Particulate Matter/chemistry
Mesh:Inhalation Exposure/adverse effects
Mesh:Lung/immunology
Mesh:Particulate Matter/toxicity
Mesh:Particle Size
Mesh:Solvents/chemistry
Inflammation
Particulate matter
Oxidative stress
General Medicine
3. Good health
medicine.anatomical_structure
Cytokine
MESH: Particulate Matter
Bronchitis
Cytokines
MESH: Inhalation Exposure
medicine.symptom
Inflammation Mediators
[SDV.IMM.ALL] Life Sciences [q-bio]/Immunology/Allergology
Colon
MESH: Inflammation Mediators
lcsh:Industrial hygiene. Industrial welfare
03 medical and health sciences
Immune system
MESH: Acetylcysteine
lcsh:RA1190-1270
MESH: Mice
Inbred C57BL
medicine
MESH: Water
Animals
[SDV.EE.SANT] Life Sciences [q-bio]/Ecology
environment/Health
MESH: Lung
MESH: Particle Size
Particle Size
MESH: Colon
0105 earth and related environmental sciences
Asthma
lcsh:Toxicology. Poisons
[SDV.EE.SANT]Life Sciences [q-bio]/Ecology
environment/Health
business.industry
Research
MESH: Antioxidants
Water
[SDV.MHEP.HEG]Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
medicine.disease
[SDV.MHEP.HEG] Life Sciences [q-bio]/Human health and pathology/Hépatology and Gastroenterology
MESH: Male
Acetylcysteine
Mice
Inbred C57BL
MESH: Solubility
030104 developmental biology
Solubility
13. Climate action
Immunology
Solvents
[SDV.MHEP.PSR] Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract
business
lcsh:HD7260-7780.8
Zdroj: Particle and Fibre Toxicology
Particle and Fibre Toxicology, 2017, 14 (1), pp.46. ⟨10.1186/s12989-017-0227-z⟩
Particle and Fibre Toxicology, BioMed Central, 2017, 14 (1), pp.46. ⟨10.1186/s12989-017-0227-z⟩
Particle and Fibre Toxicology, Vol 14, Iss 1, Pp 1-13 (2017)
ResearcherID
ISSN: 1743-8977
DOI: 10.1186/s12989-017-0227-z⟩
Popis: Background Air pollution is a recognized aggravating factor for pulmonary diseases and has notably deleterious effects on asthma, bronchitis and pneumonia. Recent studies suggest that air pollution may also cause adverse effects in the gastrointestinal tract. Accumulating experimental evidence shows that immune responses in the pulmonary and intestinal mucosae are closely interrelated, and that gut-lung crosstalk controls pathophysiological processes such as responses to cigarette smoke and influenza virus infection. Our first aim was to collect urban coarse particulate matter (PM) and to characterize them for elemental content, gastric bioaccessibility, and oxidative potential; our second aim was to determine the short-term effects of urban coarse PM inhalation on pulmonary and colonic mucosae in mice, and to test the hypothesis that the well-known antioxidant N-acetyl-L-cysteine (NAC) reverses the effects of PM inhalation. Results The collected PM had classical features of urban particles and possessed oxidative potential partly attributable to their metal fraction. Bioaccessibility study confirmed the high solubility of some metals at the gastric level. Male mice were exposed to urban coarse PM in a ventilated inhalation chamber for 15 days at a concentration relevant to episodic elevation peak of air pollution. Coarse PM inhalation induced systemic oxidative stress, recruited immune cells to the lung, and increased cytokine levels in the lung and colon. Concomitant oral administration of NAC reversed all the observed effects relative to the inhalation of coarse PM. Conclusions Coarse PM-induced low-grade inflammation in the lung and colon is mediated by oxidative stress and deserves more investigation as potentiating factor for inflammatory diseases. Electronic supplementary material The online version of this article (10.1186/s12989-017-0227-z) contains supplementary material, which is available to authorized users.
Databáze: OpenAIRE
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