Role of IL-8 rs4073 and rs2227306 polymorphisms in the development of primary gouty arthritis in a Chinese population
| Autor: | Y.X. Cui, Han Zhao, H.Q. Guo |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
medicine.medical_specialty Single-nucleotide polymorphism Gastroenterology Polymorphism Single Nucleotide law.invention 03 medical and health sciences 0302 clinical medicine Asian People Polymorphism (computer science) law Risk Factors Internal medicine Genotype Genetics medicine Humans Genetic Predisposition to Disease Allele Molecular Biology Polymerase chain reaction business.industry Arthritis Gouty Interleukin-8 030206 dentistry General Medicine Odds ratio Middle Aged Confidence interval 030211 gastroenterology & hepatology Female Restriction fragment length polymorphism business |
| Zdroj: | Genetics and molecular research : GMR. 15(4) |
| ISSN: | 1676-5680 |
| Popis: | In this study, we investigated the role of two single nucleotide polymorphisms in the promoter region of the interleukin-8 gene (IL-8; rs4073 and rs2227306) in the susceptibility to primary gouty arthritis in a Chinese population. Three hundred and twelve patients with primary gouty arthritis and 340 healthy controls were recruited from the Yan'an University Affiliated Hospital between January 2014 and March 2015. The IL-8 rs4073 and rs2227306 polymorphisms were genotyped by polymerase chain reaction combined with restriction fragment length polymorphism. Unconditional multiple-logistic regression analysis revealed that the TT genotype of rs4073 was correlated with primary gouty arthritis risk, compared to the AA genotype [adjusted odds ratio (OR) = 1.65, 95% confidence interval (CI) = 1.08-2.54; P = 0.02]. In addition, the IL-8 rs4073 T allele was associated with a significant elevated risk of primary gouty arthritis, in comparison to the A allele (OR = 1.34, 95%CI = 1.07-1.67; P = 0.01). However, we observed no significant relationship between the IL-8 rs2227306 polymorphism and primary gouty arthritis risk. The results of this study suggest that the IL-8 rs4073 polymorphism could be a marker for primary gouty arthritis development. |
| Databáze: | OpenAIRE |
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