Platelet characteristics in patients with essential thrombocytosis

Autor: Anne-Mette Hvas, Peter Buur van Kooten Niekerk, Peter H. Nissen, Mads Lamm Larsen, Oliver Heidmann Pedersen, Steen Dalby Kristensen, Erik Lerkevang Grove, Søren Bønløkke
Rok vydání: 2018
Předmět:
0301 basic medicine
Male
Platelet Aggregation
COUNT
WORLD-HEALTH-ORGANIZATION
030204 cardiovascular system & hematology
Immature Platelet
Gastroenterology
ACTIVATION
chemistry.chemical_compound
0302 clinical medicine
Platelet
COMPLICATIONS
medicine.diagnostic_test
FLOW-CYTOMETRY
Middle Aged
Flow Cytometry
Thrombosis
platelets
TURNOVER
Blood Platelets/cytology
Female
Thrombocythemia
Essential
EXPRESSION
Blood Platelets
medicine.medical_specialty
Histology
Platelet Function Tests
AGGREGOMETRY
Pathology and Forensic Medicine
Flow cytometry
03 medical and health sciences
Internal medicine
medicine
Humans
Aged
Thrombocytosis
business.industry
Platelet Count
flow cytometry
Thrombocythemia
Essential/diagnosis
Cell Biology
AGGREGATION
medicine.disease
essential thrombocytosis
THROMBOSIS
Adenosine diphosphate
030104 developmental biology
chemistry
business
Cytometry
platelet function testing
Blood sampling
Zdroj: Pedersen, O H, Larsen, M L, Grove, E L, van Kooten Niekerk, P B, Bønløkke, S, Nissen, P H, Kristensen, S D & Hvas, A-M 2018, ' Platelet Characteristics in Patients with Essential Thrombocytosis ', Cytometry. Part B: Clinical Cytometry, vol. 94, no. 6, pp. 918-927 . https://doi.org/10.1002/cyto.b.21642
ISSN: 1552-4957
DOI: 10.1002/cyto.b.21642
Popis: BACKGROUND: Essential thrombocytosis (ET) is a myeloproliferative disorder characterized by an increased platelet count. ET is associated with an increased risk of thrombosis, and procoagulant features of the disease may include an increased number of reactive reticulated platelets and an increased aggregation potential. We aimed to explore the association between platelet count, platelet turnover and platelet aggregation in patients with ET.METHODS: We included 24 ET patients who discontinued antiplatelet therapy prior to blood sampling. Reticulated platelets were assessed as immature platelet count and immature platelet fraction by automated flow cytometry (Sysmex XE-5000). Platelet aggregation was investigated by impedance aggregometry (Multiplate® Analyzer) and aggregation potential by flow cytometry (NAVIOS).RESULTS: Our results showed that ET patients had increased immature platelet count compared to healthy individuals (median 12.3 vs. median 6.9, P CONCLUSIONS: The study showed that ET patients compared to healthy individuals have an increased amount of reticulated platelets and increased aggregation potential. These findings might in part explain the increased thromboembolic risk in patients with ET This article is protected by copyright. All rights reserved.
Databáze: OpenAIRE
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